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首页> 外文期刊>Neuromuscular disorders: NMD >Performance of individual items of the quantitative myasthenia gravis score
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Performance of individual items of the quantitative myasthenia gravis score

机译：重症肌无力定量评分各个项目的表现

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We evaluated the quantitative myasthenia gravis score to determine which items better discriminate among patients and are most responsive to treatment. Current scoring ranges were compared to updated normative data when appropriate. Data from a previous study of intravenous immunoglobulin versus placebo in myasthenia gravis were analyzed. Each item of the quantitative myasthenia gravis score was analyzed for distribution, responsiveness and inter-item correlations. Items on swallowing, speaking and vital capacity had marked floor effects as did grip strength based on current normative data. The timed measures were responsive to treatment but diplopia, vital capacity and grip strength were not. Ocular items were not correlated with bulbar and generalized items (p> 0.05), suggesting multi-dimensionality. Contralateral arm and leg tests were highly correlated (r> 0.9, p< 0.001), indicating redundancy. In summary, we found that the bulbar items and grip strength did not perform well. Timed items from the Quantitative Myasthenia Gravis Score, representing fatigability, are responsive to change and we propose new ranges based on updated normative data.
机译：我们评估了定量性重症肌无力评分，以确定哪些项目可以更好地区分患者并且对治疗反应最敏感。适当时将当前评分范围与更新后的规范数据进行比较。分析了先前对重症肌无力进行静脉免疫球蛋白与安慰剂研究的数据。分析定量性重症肌无力评分的每个项目的分布，反应性和项目间相关性。根据当前的标准数据，吞咽，说话和肺活量方面的项目具有明显的地板效应，握力也很明显。定时措施对治疗有反应，但复视，肺活量和握力没有作用。眼科项目与延髓和广义项目无关（p> 0.05），提示其多维性。对侧手臂和腿部测试高度相关（r> 0.9，p <0.001），表明存在冗余。总而言之，我们发现球根项目和抓地力表现不佳。定量重症肌无力评分的定时项目（代表易疲劳性）对变化有所响应，我们根据更新的规范性数据提出新的范围。

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