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首页> 外文期刊>Neuromuscular disorders: NMD >The cranial sartorius muscle undergoes true hypertrophy in dogs with golden retriever muscular dystrophy.
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The cranial sartorius muscle undergoes true hypertrophy in dogs with golden retriever muscular dystrophy.

机译:患有金毛猎犬型肌营养不良症的狗的颅缝肌真正肥大。

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摘要

The degree of atrophy or hypertrophy of selected pelvic limb muscles was determined in the canine homologue of Duchenne muscular dystrophy. While most muscles were atrophied, the caudal and cranial sartorius were hypertrophied. Cranial sartorius weights were corrected for body weight and endomysial space to determine true muscle weights (g/kg; mean+/-SD) in three golden retriever muscular dystrophy age groups, 4-10 (Group 1; n=15), 13-26 (Group 2; n=4), and 33-66 (Group 3; n=4) months and grouped normal dogs (6-20 months; n=12). Group 1 golden retriever muscular dystrophy weights (2.2063+/-0.6884) were greater than those of normal dogs (1.2699+/-0.1966), indicating that young golden retriever muscular dystrophy dogs have true cranial sartorius muscle hypertrophy. Values of Group 2 (1.3758+/-0.5078) and Group 3 (0.5720+/-0.2423) golden retriever muscular dystrophy dogs were less than those of Group 1, suggesting that the cranial sartorius muscle atrophies over time. Given that cranial sartorius muscle weight correlated with tarsal joint angle in affected dogs (r=-0.817), the hypertrophied muscle may play a role analogous to iliotibial band tightness in Duchenne muscular dystrophy.
机译:确定的盆腔四肢肌肉萎缩或肥大程度是在杜兴肌营养不良的犬同系物中确定的。虽然大多数肌肉都萎缩了,但是尾部和颅骨的缝线都肥大了。校正了颅缝肌的体重和肌内膜间隙,以确定三个黄金猎犬肌肉营养不良症年龄组(4-10岁,第1组; n = 15),13-26岁的真实肌肉重量(g / kg;平均值+/- SD) (第2组; n = 4)和33-66(第3组; n = 4)个月,并分组正常犬(6-20个月; n = 12)。第1组金毛肌营养不良症的体重(2.2063 +/- 0.6884)大于正常犬的体重(1.2699 +/- 0.1966),这表明年轻的金毛肌营养不良犬具有真正的颅缝肌肌肥大。第2组(1.3758 +/- 0.5078)和第3组(0.5720 +/- 0.2423)的金毛寻回性肌营养不良犬的值小于第1组的值,表明颅内缝线肌萎缩症随时间推移而消失。考虑到患病犬的颅缝肌重量与关节角相关(r = -0.817),肥大的肌肉可能起着杜兴氏肌营养不良症患者胫束紧的作用。

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