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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas
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Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas

机译：VEGF和基质金属蛋白酶9在幕上性良性脑膜瘤相关的瘤周脑水肿中的作用

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摘要

Accumulating evidence indicates that VEGF and matrix metalloproteinase-9 (MMP-9) play a central role in the development of peritumoral brain edema (PTBE) associated with human brain tumors. However, the roles of these proteins, particularly of MMP-9, in PTBE associated with benign meningiomas have not been elucidated. We investigated the association between clinical features and biological factors, such as VEGF and MMP-9, and the incidence of PTBE and edema index (EI) in 60 patients with benign meningiomas. In this study, supratentorial lesions were examined for evaluating the extent of PTBE in the surrounding normal brain tissue. VEGF and MMP-9 expression was immunohistochemically examined. Multivariate analysis revealed that the presence of pial blood supply (odds ratio [OR] 12.250; P=0.0096) and VEGF (OR 7.683; P=0.0155), but not MMP-9 (OR 1.178; P=0.8113), expression are significant factors that independently predict the incidence of PTBE and influence EI. VEGF (P=0.0397) and MMP-9 (P=0.0057) expression correlates with the presence of pial blood supply. Moreover, tumors with high VEGF and MMP-9 expression had higher EIs than those with high expression of either (P=0.030). Our findings suggest that MMP-9 expression was positively related to VEGF expression and pial blood supply and promoted the occurrence of PTBE by inducing the disruption of the arachnoid membrane and formation of pial blood supply.
机译：越来越多的证据表明，VEGF和基质金属蛋白酶9（MMP-9）在与人脑肿瘤相关的肿瘤周围脑水肿（PTBE）的形成中起着重要作用。但是，尚未阐明这些蛋白质，特别是MMP-9在与良性脑膜瘤相关的PTBE中的作用。我们调查了60例良性脑膜瘤患者的临床特征和生物学因素（例如VEGF和MMP-9）与PTBE和水肿指数（EI）的发生之间的关联。在这项研究中，检查了幕上病变以评估周围正常脑组织中PTBE的程度。免疫组织化学检查了VEGF和MMP-9的表达。多变量分析显示存在部分血液供应（比值比[OR] 12.250; P = 0.0096）和VEGF（OR 7.683; P = 0.0155），但不存在MMP-9（OR 1.178; P = 0.8113），表达显着独立预测PTBE发生率并影响EI的因素。 VEGF（P = 0.0397）和MMP-9（P = 0.0057）的表达与静脉血液供应有关。此外，VEGF和MMP-9高表达的肿瘤的EIs均高于二者之一的高表达（P = 0.030）。我们的研究结果表明，MMP-9表达与VEGF表达和部分血液供应呈正相关，并通过诱导蛛网膜的破坏和部分血液供应的形成促进PTBE的发生。

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