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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Phosphorylated α-synuclein immunoreactivity in the posterior pituitary lobe
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Phosphorylated α-synuclein immunoreactivity in the posterior pituitary lobe

机译：垂体后叶的磷酸化α-突触核蛋白免疫反应

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摘要

Parkinson's disease is now recognized as a major form of α-synucleinopathy involving both the central and peripheral nervous systems. However, no research has focused on the posterior pituitary lobe (PPL), despite the fact that this organ also plays an important role in systemic homeostasis. In the present study, we aimed to distinguish phosphorylated α-synuclein (pαSyn)-positive deposits in the PPL, as is observed in Lewy body- and non-Lewy body-related disorders. PαSyn deposits were immunohistochemically analyzed using formalin-fixed, paraffin-embedded PPL specimens obtained from 60 autopsy cases. Among the cases with Lewy body-related disorders, PPL pαSyn deposits were observed in almost all cases of Parkinson's disease (22/23), and in one case of dementia with Lewy bodies (1/1). On the other hand, only 3/36 cases of non-Lewy body-related disorders had pαSyn immunoreactivity in the PPL. The present study confirms the presence of pαSyn-positive deposits, as demonstrated by high specificity (97.1%) and sensitivity (88.5%), in both Parkinson's disease and dementia with Lewy bodies, suggesting that this finding can be a useful hallmark of Lewy body-related disorders.
机译：帕金森氏病现已被认为是涉及中枢神经系统和周围神经系统的α-突触核蛋白病的主要形式。然而，尽管该器官在全身动态平衡中也起着重要作用，但尚未有关于垂体后叶（PPL）的研究。在本研究中，我们旨在区分PPL中的磷酸化α-突触核蛋白（pαSyn）阳性沉积物，正如在路易体和非路易体相关疾病中观察到的那样。使用从60例尸检病例中获得的福尔马林固定，石蜡包埋的PPL标本对PαSyn沉积物进行免疫组织化学分析。在路易体相关疾病的病例中，几乎所有帕金森病病例（22/23）和1例路易体痴呆病例（1/1）均观察到PPLpαSyn沉积。另一方面，只有3/36例非路易体相关疾病在PPL中具有pαSyn免疫反应性。本研究证实帕金森氏病和路易小体痴呆患者均具有高特异性（97.1％）和敏感性（88.5％）证明存在pαSyn阳性沉积物，表明这一发现可能是路易小体的有用标志相关疾病。

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