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首页> 外文期刊>Neuron >Molecular microcircuitry underlies functional specification in a basal ganglia circuit dedicated to vocal learning
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Molecular microcircuitry underlies functional specification in a basal ganglia circuit dedicated to vocal learning

机译：分子微电路是基础神经节电路中用于语音学习的功能规范的基础

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摘要

Similarities between speech and birdsong make songbirds advantageous for investigating the neurogenetics of learned vocal communication-a complex phenotype probably supported by ensembles of interacting genes in cortico-basal ganglia pathways of both species. To date, only FoxP2 has been identified as critical to both speech and birdsong. We performed weighted gene coexpression network analysis on microarray data from singing zebra finches to discover gene ensembles regulated during vocal behavior. We found ～2,000 singing-regulated genes comprising three coexpression groups unique to area X, the basal ganglia subregion dedicated to learned vocalizations. These contained known targets of human FOXP2 and potential avian targets. We validated biological pathways not previously implicated in vocalization. Higher-order gene coexpression patterns, rather than expression levels, molecularly distinguish area X from the ventral striato-pallidum during singing. The previously unknown structure of singing-driven networks enables prioritization of molecular interactors that probably bear on human motor disorders, especially those affecting speech.
机译：语音和鸟鸣声之间的相似性使鸣禽有利于研究学习的人声交流的神经遗传学-这是一个复杂的表型，可能由两个物种的皮质-基底神经节通路中相互作用基因的集合所支持。迄今为止，只有FoxP2被认为对语音和鸟鸣声至关重要。我们对唱歌的斑马雀科动物的微阵列数据进行了加权基因共表达网络分析，以发现在声乐行为中受到调控的基因组。我们发现了约2,000个由唱歌调节的基因，这些基因由三个共同表达组组成，这是区域X所特有的，该区域是专门用于学习发声的基底神经节子区域。这些包含人类FOXP2的已知靶标和潜在的鸟类靶标。我们验证了以前与发声无关的生物学途径。在唱歌过程中，高阶基因共表达模式而非表达水平在分子上将区域X与腹侧纹状体-苍白球区分开。唱歌驱动网络的以前未知的结构使得能够优先考虑可能影响人类运动障碍（尤其是影响言语的那些）的分子相互作用子。

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