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首页> 外文期刊>Neuron >The SOL-2/Neto Auxiliary Protein Modulates the Function of AMPA-Subtype Ionotropic Glutamate Receptors
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The SOL-2/Neto Auxiliary Protein Modulates the Function of AMPA-Subtype Ionotropic Glutamate Receptors

机译：SOL-2 / Neto辅助蛋白调节AMPA亚型离子型谷氨酸受体的功能

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摘要

The neurotransmitter glutamate mediates excitatory synaptic transmission by gating ionotropic glutamate receptors (iGluRs). AMPA receptors (AMPARs), a subtype of iGluR, are strongly implicated in synaptic plasticity, learning, and memory. We previously discovered two classes of AMPAR auxiliary proteins in C. elegans that modify receptor kinetics and thus change synaptic transmission. Here, we have identified another auxiliary protein, SOL-2, a CUB-domain protein that associates with both the related auxiliary subunit SOL-1 and with the GLR-1 AMPAR. In sol-2 mutants, behaviors dependent on glutamatergic transmission are disrupted, GLR-1-mediated currents are diminished, and GLR-1 desensitization and pharmacology are modified. Remarkably, a secreted variant of SOL-1 delivered in trans can rescue sol-1 mutants, and this rescue depends on in cis expression of SOL-2. Finally, we demonstrate that SOL-1 and SOL-2 have an ongoing role in the adult nervous system to control AMPAR-mediated currents. Wang et al. identify SOL-2 and SOL-1, CUB-domain proteins that bind to the GLR-1 AMPA subtype of glutamate receptor in C. elegans. SOL-2 is required in the adult, and GLR-1-mediated behavior, currents, and receptor pharmacology are disrupted in sol-2 mutants.
机译：谷氨酸神经递质通过控制离子型谷氨酸受体（iGluRs）介导兴奋性突触传递。 AMPA受体（AMPA）是iGluR的一种亚型，与突触可塑性，学习和记忆密切相关。我们之前在秀丽隐杆线虫中发现了两类AMPAR辅助蛋白，它们可以改变受体动力学，从而改变突触传递。在这里，我们确定了另一种辅助蛋白SOL-2，一种与相关辅助亚基SOL-1和GLR-1 AMPAR相关的CUB结构域蛋白。在sol-2突变体中，依赖于谷氨酸能传递的行为被破坏，GLR-1介导的电流减少，并且GLR-1脱敏和药理学被改变。值得注意的是，以反式传递的SOL-1分泌型变体可以拯救sol-1突变体，而这种拯救取决于SOL-2的顺式表达。最后，我们证明SOL-1和SOL-2在成人神经系统中具有持续的作用，以控制AMPAR介导的电流。 Wang等。鉴定与线虫中谷氨酸受体的GLR-1 AMPA亚型结合的SOL-2和SOL-1，CUB域蛋白。成人需要SOL-2，而sol-2突变体会破坏GLR-1介导的行为，电流和受体药理作用。

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