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The Role of Medial Prefrontal Cortex in Memory and Decision Making

机译:内侧前额叶皮层在记忆和决策中的作用

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Some have claimed that the medial prefrontal cortex (mPFC) mediates decision making. Others suggest mPFC is selectively involved in the retrieval of remote long-term memory. Yet others suggests mPFC supports memory and consolidation on time scales ranging from seconds to days. How can all these roles be reconciled? We propose that the function of the mPFC is to learn associations between context, locations, events, and corresponding adaptive responses, particularly emotional responses. Thus, the ubiquitous involvement of mPFC in both memory and decision making may be due to the fact that almost all such tasks entail the ability to recall the best action or emotional response to specific events in a particular place and time. An interaction between multiple memory systems may explain the changing importance of mPFC to different types of memories over time. In particular, mPFC likely relies on the hippocampus to support rapid learning and memory consolidation. In this review, Euston, Gruber, and McNaughton propose that the function of the mPFC is to learn associations among context, locations, events, and corresponding adaptive responses, particularly emotional responses.
机译:一些人声称内侧前额叶皮层(mPFC)介导决策。其他人则建议mPFC选择性地参与远程长期记忆的检索。还有一些建议表明,mPFC支持在数秒到数天的时间范围内进行存储和合并。如何协调所有这些角色?我们建议,mPFC的功能是学习背景,位置,事件和相应的适应性反应(尤其是情绪反应)之间的关联。因此,mPFC普遍参与记忆和决策可能是由于以下事实:几乎所有此类任务都需要具有回忆起在特定时间和地点对特定事件做出最佳动作或情感反应的能力。多个内存系统之间的交互可能解释了随着时间的推移,mPFC对不同类型的内存的重要性不断变化。特别是,mPFC可能依赖海马来支持快速学习和记忆巩固。在这篇评论中,Euston,Gruber和McNaughton提出,mPFC的功能是学习背景,位置,事件以及相应的适应性反应(尤其是情绪反应)之间的关联。

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    《Neuron》 |2012年第6期|共14页
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  • 正文语种 eng
  • 中图分类 神经病学;
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