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Studying brain organization via spontaneous fMRI signal

机译:通过自发性功能磁共振成像信号研究大脑组织

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In recent years, some substantial advances in understanding human (and nonhuman) brain organization have emerged from a relatively unusual approach: the observation of spontaneous activity, and correlated patterns in spontaneous activity, in the "resting" brain. Most commonly, spontaneous neural activity is measured indirectly via fMRI signal in subjects who are lying quietly in the scanner, the so-called "resting state." This Primer introduces the fMRI-based study of spontaneous brain activity, some of the methodological issues active in the field, and some ways in which resting-state fMRI has been used to delineate aspects of area-level and supra-areal brain organization. Human brain organization, in health and disease, is increasingly studied by measuring spontaneous brain activity with fMRI. This Primer explains how researchers study these fMRI signals, and what these signals might reveal about brain organization.
机译:近年来,在一种相对不寻常的方法中,人们对人类(和非人类)大脑组织的理解有了一些实质性的进步:在“静止”的大脑中观察自发活动以及相关的自发活动模式。最常见的是,在安静地躺在扫描仪中的受试者(称为“静止状态”)中,通过fMRI信号间接测量自发性神经活动。本入门指南介绍了基于fMRI的自发性大脑活动的研究,该领域活跃的一些方法学问题,以及使用静息状态fMRI来描述区域级别和区域上方大脑组织方面的一些方式。通过fMRI测量自发性大脑活动,越来越多地研究了人类大脑在健康和疾病方面的组织。本入门手册解释了研究人员如何研究这些功能磁共振成像信号,以及这些信号可能揭示出有关大脑组织的信息。

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