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首页> 外文期刊>Neuron >Complementary roles for primate frontal and parietal cortex in guarding working memory from distractor stimuli
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Complementary roles for primate frontal and parietal cortex in guarding working memory from distractor stimuli

机译：灵长类额叶和顶叶皮层在保护工作记忆免受干扰物刺激方面的辅助作用

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Prefrontal cortex (PFC) and posterior parietal cortex are important for maintaining behaviorally relevant information in working memory. Here, we challenge the commonly held view that suppression of distractors by PFC neurons is the main mechanism underlying the filtering of task-irrelevant information. We recorded single-unit activity from PFC and the ventral intraparietal area (VIP) of monkeys trained to resist distracting stimuli in a delayed-match-to-numerositytask. Surprisingly, PFC neurons preferentially encoded distractors during their presentation. Shortly after this interference, however, PFC neurons restored target information, which predicted correct behavioral decisions. In contrast, most VIPneurons only encoded target numerosities throughout the trial. Representation of target information in VIP was the earliest and most reliable neuronal correlate of behavior. Our data suggest that distracting stimuli can be bypassed by storing and retrieving target information, emphasizing active maintenance processes during working memory with complementary functions for frontal and parietal cortex in controlling memory content.
机译：前额叶皮层（PFC）和顶叶后部皮层对于在工作记忆中维持行为相关信息很重要。在这里，我们挑战一种普遍的观点，即PFC神经元抑制干扰物是过滤与任务无关的信息的主要机制。我们记录了从PFC和受训的猴子的腹顶壁内区域（VIP）的单单位活动，这些猴子经过训练可以抵抗分散的对数字的任务中的分散注意力的刺激。出人意料的是，PFC神经元在出现时会优先编码干扰物。然而，在这种干扰之后不久，PFC神经元恢复了目标信息，该信息预测了正确的行为决策。相比之下，大多数VIPneurons在整个试验过程中仅编码目标数量。 VIP中目标信息的表示是行为的最早且最可靠的神经元关联。我们的数据表明，可以通过存储和检索目标信息来绕开分散注意力的刺激，强调工作记忆期间的主动维护过程，并具有额叶和顶叶皮层的互补功能来控制记忆内容。

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