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首页> 外文期刊>Neuron >Four GABAergic interneurons impose feeding restraint in Drosophila
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Four GABAergic interneurons impose feeding restraint in Drosophila

机译:四个GABA能神经元限制果蝇的摄食

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Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establish a central feeding threshold which is required to inhibit consumption. Inactivation of these cells results in indiscriminate and excessive intake of all compounds, independent of taste quality or nutritional state. Conversely, acute activation of these neurons suppresses consumption of water and nutrients. The output from these neurons is required to gate activity in motor neurons that control meal initiation and consumption. Thus, our study reveals a layer of inhibitory control in feeding circuits that is required to suppress a latent state of unrestricted and nonselective consumption.
机译:食物的适口性和动物的生理需要动态地调节喂养。如何通过外部感官提示和内部代谢状态控制消费尚待深入研究。在这里,我们确定了果蝇大脑中的四个GABA能中间神经元,它们建立了抑制摄入所需的中心进食阈值。这些细胞的失活导致所有化合物的滥入和过量摄入,而与口味质量或营养状态无关。相反,这些神经元的急性激活抑制了水和营养的消耗。需要这些神经元的输出来控制运动神经元的活动,从而控制进餐和进食。因此,我们的研究揭示了馈电电路中的抑制控制层,该抑制层需要抑制无限制和非选择性消耗的潜在状态。

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