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首页> 外文期刊>Neuron >CaMKI-Dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron
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CaMKI-Dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron

机译：CaMKI依赖的感觉基因表达调控在热感觉神经元的工作范围内介导经验依赖的可塑性。

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摘要

Sensory adaptation represents a form of experience-dependent plasticity that allows neurons to retain high sensitivity over a broad dynamic range. The mechanisms by which sensory neuron responses are altered on different timescales during adaptation are unclear. The threshold for temperature-evoked activity in the AFD thermosensory neurons (T* AFD) in C. elegans is set by the cultivation temperature (Tc) and regulated by intracellular cGMP levels. We find that T* AFD adapts on both short and long timescales upon exposure to temperatures warmer than Tc, and that prolonged exposure to warmer temperatures alters expression of AFD-specific receptor guanylyl cyclase genes. These temperature-regulated changes in gene expression are mediated by the CMK-1 CaMKI enzyme, which exhibits Tc-dependent nucleocytoplasmic shuttling in AFD. Our results indicate that CaMKI-mediated changes in sensory gene expression contribute to long-term adaptationof T* AFD, and suggest that similar temporally and mechanistically distinct phases may regulate the operating ranges of other sensory neurons.
机译：感觉适应性代表一种依赖于经验的可塑性，它使神经元在广泛的动态范围内保持高灵敏度。适应过程中不同时间尺度上改变感觉神经元反应的机制尚不清楚。秀丽隐杆线虫的AFD热感神经元（T * AFD）中的温度诱发活动阈值由培养温度（Tc）设置，并由细胞内cGMP水平调节。我们发现，T * AFD在暴露于比Tc更高的温度时会适应短时和长时标，而长时间暴露于温暖的温度会改变AFD特异性受体鸟苷酸环化酶基因的表达。这些温度调节的基因表达变化是由CMK-1 CaMKI酶介导的，该酶在AFD中表现出Tc依赖性核质穿梭。我们的结果表明，CaMKI介导的感觉基因表达变化有助于T * AFD的长期适应，并表明相似的时间和机理上不同的阶段可能会调节其他感觉神经元的工作范围。

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