An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles.

Pun S; Sigrist M; Santos AF; Ruegg MA; Sanes JR; Jessell TM; Arber S; Caroni P

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An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles.

机译：不同骨骼肌中神经肌肉接头组装和维持的固有区别。

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We analyzed the formation of neuromuscular junctions (NMJs) in individual muscles of the mouse embryo. Skeletal muscles can be assigned to one of two distinct classes of muscles, termed "Fast Synapsing" (FaSyn) and Delayed Synapsing respect to the initial focal clustering of postsynaptic AChRs, the timing of presynaptic maturation, and the maintenance of NMJs in young adult mice. Differences between classes were intrinsic to the muscles and manifested in the absence of innervation or agrin. Paralysis or denervation of young adult muscles resulted in disassembly of AChR clusters on DeSyn muscles, whereas those on FaSyn muscles were preserved. Our results show that postsynaptic differentiation processes intrinsic to FaSyn and DeSyn muscles influence the formation of NMJs during development and their maintenance in the adult.

机译：我们分析了小鼠胚胎单个肌肉中神经肌肉接头（NMJs）的形成。可以将骨骼肌分配给两种不同类别的肌肉之一，分别称为“快速突触”（FaSyn）和“延迟突触”，它们涉及幼年成年小鼠的突触后AChR的初始局灶性聚集，突触前成熟的时间以及NMJ的维持。类别之间的差异是肌肉固有的，表现在没有神经支配或凝集素的情况下。年轻的成年肌肉瘫痪或失神经导致DeSyn肌肉上的AChR簇解体，而FaSyn肌肉上的AChR簇得以保留。我们的研究结果表明，FaSyn和DeSyn肌肉固有的突触后分化过程会影响NMJ在成人的发育和维持过程中的形成。

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《Neuron》 |2002年第3期|共14页
作者
Pun S; Sigrist M; Santos AF; Ruegg MA; Sanes JR; Jessell TM; Arber S; Caroni P;
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正文语种 eng
中图分类神经生理学;
关键词
Muscle; Skeletal; Neuromuscular Junction; Receptors; Cholinergic; 肌; 骨骼; 神经肌肉接头; 受体; 胆碱能;

机译：Muscle;Skeletal;Neuromuscular Junction;Receptors;Cholinergic;肌;骨骼;神经肌肉接头;受体;胆碱能;

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专利

1. An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles. [J] . Pun S, Sigrist M, Santos AF, Neuron . 2002,第3期

机译：不同骨骼肌中神经肌肉接头组装和维持的固有区别。
2. Overexpression of Dok-7 in skeletal muscle enhances neuromuscular transmission with structural alterations of neuromuscular junctions: Implications in robustness of neuromuscular transmission [J] . Biochemical and Biophysical Research Communications . 2020,第1期

机译：DOK-7在骨骼肌中的过度表达增强了神经肌肉连接的结构改变的神经肌肉传播：神经肌肉传输的鲁棒性的影响
3. Does IARS2 Deficiency Cause an Intrinsic Disorder of Bone Development (Skeletal Dysplasia) or Are the Reported Skeletal Changes Secondary to Growth Hormone Deficiency and Neuromuscular Involvement? (vol 36, pg 388, 2015) [J] . Mordaunt Dylan A., Savarirayan Ravi Human mutation . 2016,第3期

机译：IARS2缺乏症是否会引起骨发育的内在紊乱（骨骼发育不良），或者所报告的骨骼变化是继发于生长激素缺乏症和神经肌肉活动的继发性疾病？（2015年第36卷，第388页）
4. DISTRIBUTION OF ACETYL-CHOLINE RECEPTORS AND POST-SYNAPTIC NEUROMUSCULAR JUNCTION PROTEINS IN SKELETAL MUSCLE TISSUE [C] . T. S. Faulmann, L. Engelbrecht, K. H. Myburgh Annual Conference of the Microscopy Society of Southern Africa . 2016

机译：乙酰胆碱受体和突触后神经肌肉接线蛋白在骨骼肌组织中的分布
5. Synapse maintenance and function at the mouse neuromuscular junction: Implications in diseases. [D] . Lin, Ming-Yi. 2011

机译：小鼠神经肌肉连接处的突触维持和功能：对疾病的影响。
6. Neuromuscular junctions and alpha-bungarotoxin-binding sites in denervated and contralateral cat skeletal muscles. [O] . J H Steinbach 1981

机译：失神经的和对侧猫骨骼肌中的神经肌肉接头和α-真菌毒素结合位点。
7. An Intrinsic Distinction in Neuromuscular Junction Assembly and Maintenance in Different Skeletal Muscles [O] . Pun San, Sigrist Markus, Santos Alexandre F., 2002

机译：不同骨骼肌神经肌肉连接组装和维持的内在区别

An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles.

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