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首页> 外文期刊>Neuron >Inflammation in neurodegenerative disease--a double-edged sword.
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Inflammation in neurodegenerative disease--a double-edged sword.

机译：神经退行性疾病中的炎症-双刃剑。

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摘要

Inflammation is a defense reaction against diverse insults, designed to remove noxious agents and to inhibit their detrimental effects. It consists of a dazzling array of molecular and cellular mechanisms and an intricate network of controls to keep them in check. In neurodegenerative diseases, inflammation may be triggered by the accumulation of proteins with abnormal conformations or by signals emanating from injured neurons. Given the multiple functions of many inflammatory factors, it has been difficult to pinpoint their roles in specific (patho)physiological situations. Studies of genetically modified mice and of molecular pathways in activated glia are beginning to shed light on this issue. Altered expression of different inflammatory factors can either promote or counteract neurodegenerative processes. Since many inflammatory responses are beneficial, directing and instructing the inflammatory machinery may be a better therapeutic objective than suppressing it.
机译：炎症是针对多种侮辱的防御反应，旨在消除有害物质并抑制其有害作用。它由令人眼花molecular乱的分子和细胞机制以及复杂的控制网络组成，以使它们处于受控状态。在神经退行性疾病中，炎症可能是由具有异常构象的蛋白质积累或由受损神经元发出的信号引起的。考虑到许多炎症因子的多种功能，很难确定它们在特定（病理）生理情况下的作用。转基因小鼠和活化神经胶质细胞分子途径的研究开始阐明这一问题。不同炎症因子表达的改变可以促进或抵消神经退行性过程。由于许多炎症反应都是有益的，因此与抑制炎症机制相比，指导和指导炎症机制可能是更好的治疗目标。

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