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首页> 外文期刊>Neuron >Asymmetric growth and development of the Xenopus laevis retina during metamorphosis is controlled by type III deiodinase.
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Asymmetric growth and development of the Xenopus laevis retina during metamorphosis is controlled by type III deiodinase.

机译：异型非洲爪蟾视网膜的不对称生长和发育受III型脱碘酶控制。

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摘要

During the metamorphosis of the Xenopus laevis retina, thyroid hormone (TH) preferentially induces ventral ciliary marginal zone (CMZ) cells to both increase their proliferation and give rise to ipsilaterally projecting ganglion cells. Here we show that dorsal CMZ cells express type III deiodinase (D3), an enzyme that inactivates TH. The dorsal CMZ cells can be induced to proliferate if deiodinase activity is inhibited. D3 or dominant-negative thyroid hormone receptor transgenes inhibit both TH-induced proliferation of the ventral CMZ cells and the formation of the ipsilateral projection. Thus, the localized expression of D3 in the dorsal CMZ cells accounts for the asymmetric growth of the frog retina.
机译：在非洲爪蟾视网膜变态过程中，甲状腺激素（TH）优先诱导腹侧睫状边缘区（CMZ）细胞增加增殖并产生同侧突出的神经节细胞。在这里，我们显示了背部CMZ细胞表达III型脱碘酶（D3），该酶可灭活TH。如果脱碘酶活性受到抑制，则可以诱导背侧CMZ细胞增殖。 D3或显性阴性甲状腺激素受体转基因既抑制TH诱导的腹侧CMZ细胞增殖，又抑制同侧突起的形成。因此，D3在背部CMZ细胞中的局部表达解释了青蛙视网膜的不对称生长。

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