Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans (see comments)

Miller KG; Emerson MD; Rand JB

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Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans (see comments)

机译：Goalpha和二酰基甘油激酶对秀丽隐杆线虫中的Gqalpha通路有负调控作用（请参阅评论）

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We investigated the EGL-30 (Gqalpha) pathway in C. elegans by using genetic screens to identify genes that confer phenotypes similar to egl-30 mutants. One such gene, egl-8, encodes a phospholipase Cbeta that is present throughout the nervous system and near intestinal cell junctions. EGL-30 and EGL-8 appear to positively regulate synaptic transmission because reducing their function results in strong aldicarb resistance and slow locomotion rates. In contrast, GOA-1 (Goalpha) and DGK-1 (diacylglycerol kinase) appear to negatively regulate synaptic transmission, because reducing their function results in strong aldicarb hypersensitivity and hyperactive locomotion. A genetic analysis suggests that GOA-1 negatively regulates the EGL-30 pathway and that DGK-1 antagonizes the EGL-30 pathway.

机译：我们通过使用遗传筛选来鉴定秀丽隐杆线虫中的EGL-30（Gqalpha）途径，以鉴定出赋予表型类似于egl-30突变体的基因。一种这样的基因，例如egl-8，编码存在于整个神经系统和肠细胞连接附近的磷脂酶Cbeta。 EGL-30和EGL-8似乎正调节突触传递，因为降低其功能会导致强大的涕灭威抗性和缓慢的运动速度。相反，GOA-1（Goalpha）和DGK-1（二酰甘油激酶）似乎负调节突触传递，因为降低其功能会导致强烈的涕灭威超敏反应和运动过度。遗传分析表明，GOA-1负调节EGL-30途径，而DGK-1拮抗EGL-30途径。

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《Neuron》 |1999年第2期|共11页
作者
Miller KG; Emerson MD; Rand JB;
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正文语种 eng
中图分类神经生理学;
关键词
Caenorhabditis elegans; Diacylglycerol Kinase; Heterotrimeric GTP Binding Proteins physiology; 新小杆线虫; 漂亮; 二酰甘油激酶;

机译：Caenorhabditis elegans;Diacylglycerol Kinase;Heterotrimeric GTP Binding Proteins physiology;新小杆线虫;漂亮;二酰甘油激酶;

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1. Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans (see comments) [J] . Miller KG, Emerson MD, Rand JB Neuron . 1999,第2期

机译：Goalpha和二酰基甘油激酶对秀丽隐杆线虫中的Gqalpha通路有负调控作用（请参阅评论）
2. Distinct roles of the Src family kinases, SRC‐1 and KIN‐22, that are negatively regulated by CSK‐1 in C. elegans [J] . Hirose Takashi, Koga Makoto, Ohshima Yasumi, FEBS Letters . 2003,第1a3期

机译：秀丽隐杆线虫中CSK-1负调节的Src家族激酶SRC-1和KIN-22的不同作用
3. The kinases PIG-1 and PAR-1 act in redundant pathways to regulate asymmetric division in the EMS blastomere of C. elegans [J] . Liro Malgorzata J., Morton Diane G., Rose Lesilee S. Developmental biology . 2018,第1期

机译：激酶猪-1和PAR-1在冗余途径中起作用，以调节C.秀丽隐杆线虫的EMS Blastjere中的不对称分裂
4. Tuning Resistance in the Map Kinase Pathway: Lessons for Synthetic Biology from a Developmental Network in C. Elegans [C] . Claudiu Giurumescu, Stephen Chapman, Anand R. Asthagiri International Symposium on Runaway Reactions, Pressure Relief Design and Effluent Handling American Institute of Chemical Engineers/American Chemical Society Management Conference . 2005

机译：在地图激酶路径中调整抗性：来自C.秀丽隐杆线虫的发育网络的合成生物学课程
5. A map kinase-related pathway functions with the Wnt pathway to regulate anterior-posterior polarity in C. elegans. [D] . Meneghini, Marc Dennis. 2000

机译：映射激酶相关途径与Wnt途径共同作用，以调节秀丽隐杆线虫的前后极性。
6. Goα and Diacylglycerol Kinase Negatively Regulate the Gqα Pathway in C. elegans [O] . Kenneth G. Miller, Melanie D. Emerson, James B. Rand -1

机译：Goα和二酰基甘油激酶负调控线虫的Gqα途径。
7. Goα and Diacylglycerol Kinase Negatively Regulate the Gqα Pathway in C. elegans [O] . Miller Kenneth G, Emerson Melanie D, Rand James B 1999

机译：Goα和二酰基甘油激酶负调控线虫的Gqα途径。

Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans (see comments)

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