latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant (see comments)

Pinto S; Quintana DG; Smith P; Mihalek RM; Hou ZH; Boynton S; Jones CJ; Hendricks M; Velinzon K; Wohlschlegel JA; Austin RJ; Lane WS; Tully T; Dutta A

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latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant (see comments)

机译：Latheo编码起源识别复合体的一个亚基，并在突变时破坏神经元增殖和成人嗅觉记忆（请参阅注释）

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The Drosophila latheo (lat) gene was identified in a behavioral screen for olfactory memory mutants. The original hypomorphic latP1 mutant (Boynton and Tully, 1992) shows a structural defect in adult brain. Homozygous lethal lat mutants lack imaginal discs, show little cell proliferation in the CNS of third instar larvae, and die as early pupae. latP1 was cloned, and all of the above mentioned defects of hypomorphic or homozygous lethal lat mutants were rescued with a lat+ transgene. lat encodes a novel protein with homology to a subunit of the origin recognition complex (ORC). Human and Drosophila LAT both associate with ORC2 and are related to yeast ORC3, suggesting that LAT functions in DNA replication during cell proliferation.

机译：果蝇latheo（lat）基因是在嗅觉记忆突变体的行为筛选中确定的。最初的亚态latP1突变体（Boynton和Tully，1992）显示了成人大脑的结构缺陷。纯合致死性lat突变体缺乏假想盘，在三龄幼虫的中枢神经系统中几乎没有细胞增殖，并且死于早p。克隆了latP1，并使用lat +转基因挽救了上述所有亚型或纯合致死性lat突变体的缺陷。 lat编码与起源识别复合体（ORC）的一个亚基具有同源性的新型蛋白质。人和果蝇的LAT都与ORC2相关，并且与酵母ORC3有关，这表明LAT在细胞增殖过程中在DNA复制中起作用。

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《Neuron》 |1999年第1期|共10页
作者
Pinto S; Quintana DG; Smith P; Mihalek RM; Hou ZH; Boynton S; Jones CJ; Hendricks M; Velinzon K; Wohlschlegel JA; Austin RJ; Lane WS; Tully T; Dutta A;
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正文语种 eng
中图分类神经生理学;
关键词
Drosophila; DNA-Binding Proteins; Memory; Mutation; Neurons; Olfactory Pathways; 果蝇属; DNA结合蛋白质类; 记忆; 突变; 神经元; 嗅通路;

机译：Drosophila;DNA-Binding Proteins;Memory;Mutation;Neurons;Olfactory Pathways;果蝇属;DNA结合蛋白质类;记忆;突变;神经元;嗅通路;

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1. latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant (see comments) [J] . Pinto S, Quintana DG, Smith P, Neuron . 1999,第1期

机译：Latheo编码起源识别复合体的一个亚基，并在突变时破坏神经元增殖和成人嗅觉记忆（请参阅注释）
2. Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. [J] . Bicknell LS, Walker S, Klingseisen A, Nature Genetics . 2011,第4期

机译：编码起源识别复合体最大亚基的ORC1中的突变会引起类似于迈耶-戈林综合症的小头原始侏儒症。
3. Plasmodium falciparum origin recognition complex subunit 1 (PfOrc1) functionally complements Δsir3 mutant of Saccharomyces cerevisiae [J] . VarunanS.M., TripathiJ., BhattacharyyaS., Molecular and Biochemical Parasitology . 2013,第1期

机译：恶性疟原虫起源识别复合物亚基1（PfOrc1）在功能上与酿酒酵母的Δsir3突变体互补
4. The Tetrahymena origin recognition complex contains an integral RNA subunit and is differentially targeted to rDNA and non-rDNA replication origins [D] . Donti, Taraka Ramarao 2008

机译：四膜虫起源识别复合物包含一个不可或缺的RNA亚基，并针对rDNA和非rDNA复制起源进行差异靶向
5. The k43 gene required for chorion gene amplification and diploid cell chromosome replication encodes the Drosophila homolog of yeast origin recognition complex subunit 2 [O] . Gary Landis, Richard Kelley, Allan C. Spradling, 1997

机译：绒毛膜基因扩增和二倍体细胞染色体复制所需的k43基因编码酵母起源识别复合物亚基2的果蝇同源物
6. latheo Encodes a Subunit of the Origin Recognition Complex and Disrupts Neuronal Proliferation and Adult Olfactory Memory When Mutant [O] . Pinto Shirly, Quintana David G, Smith Patrick, 1999

机译：latheo编码起源识别复合物的一个亚基，并在突变时破坏神经元增殖和成人嗅觉记忆

latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant (see comments)

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