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How a circadian clock adapts to seasonal decreases in temperature and day length (see comments)

机译：昼夜节律时钟如何适应温度和白天长度的季节性减少（请参阅评论）

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摘要

We show that a thermosensitive splicing event in the 3' untranslated region of the mRNA from the period (per) gene plays an important role in how a circadian clock in Drosophila adapts to seasonally cold days (low temperatures and short day lengths). The enhanced splicing of this intron at low temperatures advances the steady state phases of the per mRNA and protein cycles, events that significantly contribute to the preferential daytime activity of flies on cold days. Because the accumulation of PER is also dependent on the photosensitive TIMELESS (TIM) protein, long photoperiods partially counteract the cold-induced advances in the oscillatory mechanism by delaying the daily increases in the levels of TIM. Our findings also indicate that there is a temperature-dependent switch in the molecular logic governing cycles in per mRNA levels.
机译：我们显示，从时期（每个）基因的mRNA的3'非翻译区域中的热敏拼接事件在果蝇的昼夜节律如何适应季节性寒冷的日子（低温和短日长）中起重要作用。内含子在低温下的增强剪接作用促进了每个mRNA和蛋白质循环的稳态阶段，这些事件极大地促进了苍蝇在寒冷天的优先白天活动。因为PER的积累还取决于光敏的TIMELESS（TIM）蛋白，所以长的光周期通过延迟TIM水平的每日增加来部分抵消冷诱导的振荡机制的进展。我们的发现还表明，在控制每个mRNA水平周期的分子逻辑中存在温度依赖性开关。

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