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首页> 外文期刊>Neuron >Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina.
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Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina.

机译：恢复素通过增强小鼠视网膜中的信号传递来改善视杆介导的视力。

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摘要

Vision in dim light requires that photons absorbed by rod photoreceptors evoke signals that reliably propagate through the retina. We investigated how a perturbation in rod physiology affects propagation of those signals in the retina and ultimately visual sensitivity. Recoverin is a protein in rods that prolongs phototransduction and enhances visual sensitivity. It is not present in neurons postsynaptic to rods, yet we found that light-evoked responses of rod bipolar and ganglion cells were shortened when measured in recoverin-deficient retinas. Unexpectedly, the effect of recoverin on postsynaptic signals could not be explained by its effect on phototransduction. Instead, it is an effect of recoverin downstream of phototransduction in rods that prolongs signal transmission and enhances visual sensitivity. An important implication of our findings is that the recovery phase of the rod photoresponse does not contribute significantly to visual sensitivity near absolute threshold.
机译：在昏暗的灯光下，视觉要求杆感光器吸收的光子发出可靠地传播通过视网膜的信号。我们研究了杆生理的微扰如何影响那些信号在视网膜中的传播以及最终的视觉敏感性。恢复蛋白是棒中的一种蛋白质，可延长光转导并增强视觉敏感性。它在杆突触后神经元中不存在，但是我们发现，在缺乏恢复蛋白的视网膜中测量时，杆双极和神经节细胞的光诱发反应会缩短。出乎意料的是，恢复素对突触后信号的作用不能通过其对光转导的作用来解释。相反，这是棒中光转导下游的恢复蛋白的作用，其延长信号传输并增强视觉灵敏度。我们发现的重要意义是棒光反应的恢复阶段对绝对阈值附近的视觉敏感性没有显着贡献。

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