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首页> 外文期刊>Neuron >Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cells.
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Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cells.

机译：在有丝分裂过程中EGFR受体的不对称分布会产生多种CNS祖细胞。

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It has been debated whether asymmetric distribution of cell surface receptors during mitosis could generate asymmetric cell divisions by yielding daughters with different environmental responsiveness and, thus, different fates. We have found that in mouse embryonic forebrain ventricular and subventricular zones, the EGFR can distribute asymmetrically during mitosis in vivo and in vitro. This occurs during divisions yielding two Nestin+ progenitor cells, via an actin-dependent mechanism. The resulting sibling progenitor cells respond differently to EGFR ligand in terms of migration and proliferation. Moreover, they express different phenotypic markers: the EGFRhigh daughter usually has radial glial/astrocytic markers, while its EGFRlow sister lacks them, indicating fate divergence. Lineage trees of cultured cortical glioblasts reveal repeated EGFR asymmetric distribution, and asymmetric divisions underlie formation of oligodendrocytes and astrocytes in clones. These data suggest that asymmetric EGFR distribution contributes to forebrain development by creating progenitors with different proliferative, migratory, and differentiation responses to ligand.
机译：有争议的是，有丝分裂过程中细胞表面受体的不对称分布是否会通过产生具有不同环境响应能力并因此产生不同命运的子代而产生不对称细胞分裂。我们发现，在小鼠胚胎前脑室和脑室下区域，EGFR在体内和体外的有丝分裂过程中可以不对称分布。这发生在分裂过程中，通过肌动蛋白依赖性机制产生两个Nestin +祖细胞。在迁移和增殖方面，所得的同胞祖细胞对EGFR配体的反应不同。此外，它们表达不同的表型标记：EGFRhigh女儿通常具有放射状神经胶质/星形胶质细胞标记，而EGFRlow姐妹则缺乏它们，表明命运不同。培养的皮质成胶质细胞的谱系树显示出重复的EGFR不对称分布，并且不对称分裂是克隆中少突胶质细胞和星形胶质细胞形成的基础。这些数据表明，不对称的EGFR分布通过创建对配体具有不同增殖，迁移和分化反应的祖细胞而有助于前脑发育。

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