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首页> 外文期刊>Neuron >Dissociable codes of odor quality and odorant structure in human piriform cortex.
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Dissociable codes of odor quality and odorant structure in human piriform cortex.

机译:人类梨状皮层中气味质量和气味结构的可分离代码。

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摘要

The relationship between odorant structure and odor quality has been a focus of olfactory research for 100 years, although no systematic correlations are yet apparent. Animal studies suggest that topographical representations of odorant structure in olfactory bulb form the perceptual basis of odor quality. Whether central olfactory regions are similarly organized is unclear. Using an olfactory version of fMRI cross-adaptation, we measured neural responses in primary olfactory (piriform) cortex as subjects smelled pairs of odorants systematically differing in quality and molecular functional group (as one critical attribute of odorant structure). Our results indicate a double dissociation in piriform cortex, whereby posterior regions encode quality (but not structure) and anterior regions encode structure (but not quality). The presence of structure-based codes suggests fidelity of sensory information arising from olfactory bulb. In turn, quality-based codes are independent of any simple structural configuration, implying that synthetic mechanisms may underlie our experience of smell.
机译:尽管尚无系统的相关性,但气味结构与气味质量之间的关系一直是嗅觉研究的重点,已有100多年的历史。动物研究表明,嗅球中的气味结构的地形图表示形成了气味质量的感知基础。中央嗅觉区域是否类似组织尚不清楚。使用嗅觉形式的fMRI交叉适应,我们测量了主要嗅觉(梨状)皮层的神经反应,因为受试者闻到的气味对在质量和分子功能组(系统中是气味结构的一个重要属性)上系统地不同。我们的结果表明梨状皮层的双重解离,从而后部区域编码质量(而不是结构),而前部区域编码结构(但不是质量)。基于结构的代码的存在表明嗅球产生的感觉信息的保真度。反过来,基于质量的代码独立于任何简单的结构配置,这意味着合成机制可能是我们嗅觉的基础。

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