...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Spike timing-dependent LTP/LTD mediates visual experience-dependent plasticity in a developing retinotectal system.
【24h】

Spike timing-dependent LTP/LTD mediates visual experience-dependent plasticity in a developing retinotectal system.

机译：尖峰时间依赖的LTP / LTD在发展中的视网膜-视网膜系统中介导视觉体验的可塑性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sensory experience plays an instructive role in the development of the nervous system. Here we showed that visual experience can induce persistent modification of developing retinotectal circuits via spike timing-dependent plasticity (STDP). Pairing light stimuli with spiking of the tectal cell induced persistent enhancement or reduction of light-evoked responses, with a dependence on the relative timing between light stimulus and postsynaptic spiking similar to that for STDP. Using precisely timed sequential three-bar stimulation to mimic a moving bar, we showed that spike timing-dependent LTP/LTD can account for the asymmetric modification of the tectal cell receptive field induced by moving bar. Furthermore, selective inhibition of signaling mediated by brain-derived neurotrophic factor and nitric oxide, which are respectively required for light-induced LTP and LTD, interfered with moving bar-induced temporally specific changes in the tectal cell responses. Together, these findings suggest that STDP can mediate sensory experience-dependent circuit refinement in the developing nervous system.
机译：感觉经验在神经系统发育中起指导作用。在这里，我们证明了视觉体验可以通过依赖于尖峰时间的可塑性（STDP）来诱导发育中的视网膜-直肠电路的持续改变。将光刺激与顶盖细胞的尖峰配对可诱导持续增强或降低光诱发的反应，其依赖于光刺激和突触后尖峰之间的相对时序，类似于STDP。使用精确定时的顺序三杆刺激模拟运动杆，我们显示了依赖于尖峰时间的LTP / LTD可以解释运动杆引起的顶盖细胞接受场的不对称修饰。此外，对光诱导的LTP和LTD分别需要的脑源性神经营养因子和一氧化氮介导的信号的选择性抑制，会干扰顶杆运动引起的顶盖细胞反应的时间特异性变化。总之，这些发现表明，STDP可以介导发育中的神经系统中与经验有关的电路细化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号