Linking calcium to Abeta and Alzheimer's disease.

Green KN; LaFerla FM

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Linking calcium to Abeta and Alzheimer's disease.

机译：将钙与Abeta和阿尔茨海默氏病联系起来。

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Recent developments point to a critical role for calcium dysregulation in the pathogenesis of Alzheimer's disease. A novel calcium-conducting channel called CALHM1 is genetically linked to the disorder and modulates Abeta production. Calcium homeostasis has also been shown to be perturbed in dendritic spines adjacent to amyloid plaques. Finally, new studies have elucidated the role by which presenilins modulate calcium signaling, including effects on SERCA2b and gating of the IP(3) receptor, and lead to Abeta production.

机译：近期的发展表明，钙失调在阿尔茨海默氏病的发病机理中起着关键作用。一种称为CALHM1的新型钙传导通道与该疾病遗传相关，并调节Abeta的产生。钙稳态也被证明在淀粉样蛋白斑块附近的树突棘中受到干扰。最后，新的研究阐明了早老蛋白调节钙信号传导的作用，包括对SERCA2b和IP（3）受体的门控的影响，并导致Abeta产生。

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《Neuron》 |2008年第2期|共5页
作者
Green KN; LaFerla FM;
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原文格式 PDF
正文语种 eng
中图分类神经生理学;
关键词
Alzheimer Disease; Amyloid beta-Protein; Animals; Calcium; Calcium Channels; 淀粉样β蛋白; 动物; 钙; 钙通道; 膜糖蛋白类;

机译：Alzheimer Disease;Amyloid beta-Protein;Animals;Calcium;Calcium Channels;淀粉样β蛋白;动物;钙;钙通道;膜糖蛋白类;

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1. Linking calcium to Abeta and Alzheimer's disease. [J] . Green KN, LaFerla FM Neuron . 2008,第2期

机译：将钙与Abeta和阿尔茨海默氏病联系起来。
2. Cell cycle-driven neuronal apoptosis specifically linked to amyloid peptide Abeta1-42 exposure is not exacerbated in a mouse model of presenilin-1 familial Alzheimer's disease. [J] . Malik B, Currais A, Soriano S Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2008,第2期

机译：在早老素-1家族性阿尔茨海默氏病的小鼠模型中，与淀粉样肽Abeta1-42暴露特别相关的细胞周期驱动的神经元凋亡不会加剧。
3. The role of Abeta-induced calcium dysregulation in the pathogenesis of Alzheimer's disease. [J] . Small DH, Gasperini R, Vincent AJ, Journal of Alzheimer's disease: JAD . 2009,第2期

机译：Abeta诱导的钙失调在阿尔茨海默氏病发病机理中的作用。
4. A Theoretical Study on Abeta_(42) Oligomers, the Effectors in Alzheimer's Disease [C] . Horn Anselm H. C., Sticht Heinrich European Conference on Chemistry for Life Sciences . 2011

机译：Abeta_（42）寡聚体，阿尔茨海默病疾病的效果的理论研究
5. Gold nanoparticles and peptoids as novel inhibitors of Abeta aggregation in Alzheimer's disease. [D] . Moore, Kelly Ann. 2013

机译：金纳米颗粒和类肽作为阿尔茨海默氏病中Abeta聚集的新型抑制剂。
6. Comparative studies on peptides representing the so-called tachykinin-like region of the Alzheimer Abeta peptide Abeta(25-35). [O] . O M El-Agnaf, G B Irvine, G Fitzpatrick, 1998

机译：对代表阿尔茨海默病Abeta肽Abeta（25-35）所谓的速激肽样区域的肽的比较研究。
7. Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease. [O] . Minerva M Carrasquillo, Olivia Belbin, Fanggeng Zou, 2010

机译：胰岛素降解酶基因（IDE）变体与IDE mRNa，abeta和阿尔茨海默氏病的一致关联。

Linking calcium to Abeta and Alzheimer's disease.

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