• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Electrical coupling mediates tunable low-frequency oscillations and resonance in the cerebellar Golgi cell network.
【24h】

Electrical coupling mediates tunable low-frequency oscillations and resonance in the cerebellar Golgi cell network.

机译：电耦合介导小脑高尔基体细胞网络中的可调低频振荡和共振。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Tonic motor control involves oscillatory synchronization of activity at low frequency (5-30 Hz) throughout the sensorimotor system, including cerebellar areas. We investigated the mechanisms underpinning cerebellar oscillations. We found that Golgi interneurons, which gate information transfer in the cerebellar cortex input layer, are extensively coupled through electrical synapses. When depolarized in vitro, these neurons displayed low-frequency oscillatory synchronization, imposing rhythmic inhibition onto granule cells. Combining experiments and modeling, we show that electrical transmission of the spike afterhyperpolarization is the essential component for oscillatory population synchronization. Rhythmic firing arises in spite of strong heterogeneities, is frequency tuned by the mean excitatory input to Golgi cells, and displays pronounced resonance when the modeled network is driven by oscillating inputs. In vivo, unitary Golgi cell activity was found to synchronize with low-frequency LFP oscillations occurring during quiet waking. These results suggest a major role for Golgi cells in coordinating cerebellar sensorimotor integration during oscillatory interactions.
机译：强直运动控制涉及整个感觉运动系统（包括小脑区域）在低频（5-30 Hz）下的振荡振荡同步。我们研究了支持小脑振荡的机制。我们发现，在小脑皮层输入层中门控信息传递的高尔基体中神经通过电突触广泛耦合。当体外去极化时，这些神经元表现出低频振荡同步，对颗粒细胞施加节律性抑制。结合实验和建模，我们表明超极化后的尖峰的电传输是振荡总体同步的基本组成部分。尽管异质性很强，但仍会出现有节奏的触发，通过对高尔基体细胞的平均兴奋性输入进行频率调谐，并在通过振荡输入驱动建模网络时显示出明显的共振。在体内，发现单一的高尔基体细胞活动与安静醒来时发生的低频LFP振荡同步。这些结果表明高尔基细胞在振荡相互作用期间协调小脑感觉运动整合的主要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号