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首页> 外文期刊>Neuron >A tyramine-gated chloride channel coordinates distinct motor programs of a Caenorhabditis elegans escape response.
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A tyramine-gated chloride channel coordinates distinct motor programs of a Caenorhabditis elegans escape response.

机译:酪胺门控氯通道协调秀丽隐杆线虫逃逸反应的不同运动程序。

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摘要

A key feature of escape responses is the fast translation of sensory information into a coordinated motor output. In C. elegans, anterior touch initiates a backward escape response in which lateral head movements are suppressed. Here, we show that tyramine inhibits head movements and forward locomotion through the activation of a tyramine-gated chloride channel, LGC-55. lgc-55 mutant animals have defects in reversal behavior and fail to suppress head oscillations in response to anterior touch. lgc-55 is expressed in neurons and muscle cells that receive direct synaptic inputs from tyraminergic motor neurons. Therefore, tyramine can act as a classical inhibitory neurotransmitter. Activation of LGC-55 by tyramine coordinates the output of two distinct motor programs, locomotion and head movements that are critical for a C. elegans escape response.
机译:逃避反应的关键特征是将感觉信息快速转换为协调的运动输出。在秀丽隐杆线虫中,前向触摸会引发向后逃逸的反应,从而抑制头部的横向运动。在这里,我们显示酪胺通过酪胺门控氯化物通道LGC-55的激活抑制头部运动和向前运动。 lgc-55突变动物在逆向行为方面有缺陷,并且不能抑制因前触摸而引起的头部振动。 lgc-55在神经元和肌肉细胞中表达,这些神经元和肌肉细胞接受来自酪氨酸能运动神经元的直接突触输入。因此,酪胺可以充当经典的抑制性神经递质。酪胺激活LGC-55可以协调两个不同的运动程序,运动和头部运动的输出,这对于秀丽隐杆线虫逃逸反应至关重要。

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