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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Changes in carbohydrate expression in the cervical spinal cord of rats during aging.
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Changes in carbohydrate expression in the cervical spinal cord of rats during aging.

机译：衰老过程中大鼠颈脊髓碳水化合物表达的变化。

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摘要

Aging is a process where histochemical changes occur. Some of these may consist of age-dependent loss of expression of some cell markers. Conversely, cell markers not expressed in young animals may be detectable in their older counterparts. Histochemical age changes in carbohydrate profiles in the spinal cord have not been documented. In order to fill this information gap lectin histochemistry and image analysis were used to characterize the histochemical age changes occurring in the cervical segments of the rat spinal cord. From a battery of 11 lectins, the more important age changes were detected with Glicine maximus (SBA)-lectin. Thus, SBA-lectin neuronal staining which was moderately positive in the cervical segments of young animals was negative in old rats. In contrast the same lectin which did not react with the ependyma of young animals strongly bound to the ependyma of senescent rats. None of the tested lectins bound to glial cells, either in young or old animals. In no case the senile animals evidenced anatomopathological changes. We conclude that although in the aged spinal cord changes in lectin histochemical binding patterns occur, they do not reflect a pathologic situation.
机译：老化是发生组织化学变化的过程。其中一些可能包括某些细胞标记物的年龄依赖性表达丧失。相反，在年幼动物中未表达的细胞标志物可能在较年长的动物中可检测到。脊髓中碳水化合物分布的组织化学年龄变化尚无记录。为了填补这一信息空白，使用凝集素组织化学和图像分析来表征大鼠脊髓颈段中发生的组织化学年龄变化。从一组11种凝集素中，发现最大的Glicine maximus（SBA）-凝集素可以改变年龄。因此，在幼小动物的颈段中呈阳性的SBA-凝集素神经元染色在成年大鼠中呈阴性。相反，不与年幼动物的室管膜反应的相同的凝集素与衰老大鼠的室管膜强烈结合。无论是幼小的动物还是年老的动物，被测凝集素均未与神经胶质细胞结合。在任何情况下，老年动物均未表现出解剖病理学改变。我们得出的结论是，尽管在老年脊髓中凝集素发生了组织化学结合模式的变化，但并未反映出病理情况。

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