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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Olig2-positive cells in glioneuronal tumors show both glial and neuronal characters: The implication of a common progenitor cell?
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Olig2-positive cells in glioneuronal tumors show both glial and neuronal characters: The implication of a common progenitor cell?

机译：胶质神经胶质瘤中的Olig2阳性细胞同时显示神经胶质和神经元特征：共同祖细胞的含义？

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摘要

Glioneuronal tumors (GNTs) are rare neoplasms consisting of both glial and neuronal components. Among the GNTs, dysembryoplastic neuroepithelial tumors (DNTs), papillary glioneuronal tumors (PGNTs), and rosette-forming glioneuronal tumors of the fourth ventricle (RGNTs) share the character of being mainly composed of small round Olig2-positive tumor cells. Using immunohistochemistry and fluorescence in situ hybridization, we examined a series of 35 GNT cases (11 DNTs, 15 PGNTs and 9 RGNTs) on the characteristics of Olig2-positive tumor cells. Histologically, Olig2-positive cells showed small round forms in most GNTs; however, there were a small number of Olig2-positive cells with neuronal morphology only in a PGNT case. These cells expressed both glial and neuronal markers by double immunostaining. With regard to labeling indices and intensity, only PGNT cells expressed neuronal markers, including α-internexin and neurofilament. These findings also suggest that some Olig2-positive PGNT cells may show neuronal differentiation. In GNTs, a considerable number of Olig2-positive cells showed immunopositivity for cyclin D1 and/or platelet-derived growth factor receptor alpha (PDGFRα), which are markers for oligodendrocyte progenitor cells. These immunostainings were particularly strong in DNTs. In RGNTs, Olig2-positive cells formed "neurocytic rosettes". Furthermore, they were also immunopositive for glial markers, including GFAP, PDGFRα and cyclin D1. These findings indicate the heterogeneous characteristics of Olig2-positive cells in GNTs, and some of them also exhibited neuronal features. So it is possible that a part of Olig2-positive GNT cells have characteristics similar to those of progenitor cells.
机译：神经胶质神经瘤（GNT）是由神经胶质和神经元组成的罕见肿瘤。在GNT中，发育不良的神经上皮肿瘤（DNT），乳头状胶质神经胶质瘤（PGNT）和第四脑室（RGNT）形成玫瑰花结的胶质神经胶质瘤具有主要由小的圆形Olig2阳性肿瘤细胞组成的特征。使用免疫组织化学和荧光原位杂交，我们检查了一系列35个GNT病例（11个DNT，15个PGNT和9个RGNT）的Olig2阳性肿瘤细胞特征。组织学上，Olig2阳性细胞在大多数GNT中呈小圆形。然而，仅在PGNT病例中，少数具有神经元形态的Olig2阳性细胞。这些细胞通过双重免疫染色表达神经胶质和神经元标记。关于标记指数和强度，仅PGNT细胞表达神经元标记，包括α-internexin和神经丝。这些发现还表明某些Olig2阳性PGNT细胞可能显示神经元分化。在GNT中，相当数量的Olig2阳性细胞对细胞周期蛋白D1和/或血小板衍生的生长因子受体α（PDGFRα）表现出免疫阳性，这是少突胶质细胞祖细胞的标志物。这些免疫染色在DNT中特别强。在RGNT中，Olig2阳性细胞形成“神经细胞玫瑰花结”。此外，它们对神经胶质标记物（包括GFAP，PDGFRα和细胞周期蛋白D1）也呈免疫阳性。这些发现表明GNT中Olig2阳性细胞的异质性，其中一些还表现出神经元特征。因此，一部分Olig2阳性GNT细胞可能具有与祖细胞相似的特征。

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