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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Metastatic ovarian carcinoma to the brain: An approach to identification and classification for neuropathologists
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Metastatic ovarian carcinoma to the brain: An approach to identification and classification for neuropathologists

机译：转移至脑部的卵巢癌：神经病理学家的识别和分类方法

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摘要

Brain metastasis is an uncommon but increasing manifestation of ovarian epithelial carcinoma and neuropathologists' collective experience with these tumors is limited. We present clinicopathological characteristics of 13 cases of brain metastases from ovarian epithelial carcinoma diagnosed at two academic institutions. The mean ages at diagnosis of the ovarian carcinoma and their subsequent brain metastases were 58.7 and 62.8 years, respectively. At the time of initial diagnosis of ovarian carcinoma the majority of patients had an advanced stage and none had brain metastases as their first manifestation of malignancy. Brain metastases tended to be multiple with ring-enhancing features on neuroimaging. Primary tumors and their brain metastases were all high-grade histologically and the histologic subtypes were: nine high-grade serous carcinoma (HGSC) cases, two clear cell carcinoma (CCC) cases and a single case each of carcinosarcoma and high-grade adenocarcinoma. A recommended histo- and immunopathological approach to these tumours are provided to aid neuropathologists in the recognition and classification of metastatic ovarian carcinoma to the brain.
机译：脑转移是罕见的，但卵巢上皮癌的表现正在增加，并且神经病理学家对这些肿瘤的集体经验是有限的。我们目前在两个学术机构诊断出的卵巢上皮癌13例脑转移的临床病理特征。诊断卵巢癌及其随后的脑转移瘤的平均年龄分别为58.7岁和62.8岁。最初诊断为卵巢癌时，大多数患者处于晚期，没有人将脑转移作为其恶性肿瘤的第一个表现。脑转移倾向于在神经影像学上具有环增强特征的多重转移。原发性肿瘤及其脑转移在组织学上均为高度分级，其组织学亚型为：9例高度浆液性癌（HGSC），2例透明细胞癌（CCC）例和1例癌肉瘤和高级别腺癌。提供了建议的针对这些肿瘤的组织病理学和免疫病理学方法，以帮助神经病理学家识别和转移到大脑的卵巢癌。

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