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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Formation of fibroblastic reticular network in the brain after infection with neurovirulent murine coronavirus
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Formation of fibroblastic reticular network in the brain after infection with neurovirulent murine coronavirus

机译：神经毒性鼠冠状病毒感染后脑中的成纤维网状网络的形成

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摘要

cl-2 virus is an extremely neurovirulent murine coronavirus. However, during the initial phase of infection between 12 and 24 h post-inoculation (hpi), the viral antigens are detected only in the meninges, followed by viral spread into the ventricular wall before invasion into the brain parenchyma, indicating that the viruses employ a passage between the meninges and ventricular wall as an entry route into the brain parenchyma. At 48 hpi, the passage was found to be constructed by ER-TR7 antigen (ERag)-positive fibers (ERfibs) associated with laminin and collagen III between the fourth ventricle and meninges at the cerebellopontine angle. The construct of the fibers mimics the reticular fibers of the fibroblastic reticular network, which comprises a conduit systemin the lymphoid organs. In the meninges, ERfibs together with collagen fibers, lining in a striped pattern, made up a pile of thin sheets. In the brain parenchyma, mature ERfibs associated with laminin were found around blood vessels. Besides mature ERfibs, immature Erfibs without associations with other extracellular matrix components like laminin and collagen appeared after infection, suggesting that the CNS creates a unique conduit system for immune communication triggered by viral invasion.
机译：cl-2病毒是一种极具神经毒性的鼠冠状病毒。但是，在感染后的最初阶段（接种后12至24小时），仅在脑膜中检测到病毒抗原，随后病毒扩散到脑室壁中，然后侵入脑实质，这表明该病毒使用了脑膜和心室壁之间的通道，作为进入脑实质的通道。在48 hpi时，发现通道是由小脑桥脑角与第四脑室和脑膜之间的层粘连蛋白和胶原III相关的ER-TR7抗原（ERag）阳性纤维（ERfib）构成的。纤维的构造模仿了成纤维网状网络的网状纤维，其在淋巴器官中包括导管系统。在脑膜中，ERfib和胶原纤维一起衬成条纹状，形成一堆薄片。在脑实质中，在血管周围发现了与层粘连蛋白相关的成熟ERfib。除了成熟的ERfibs，感染后还会出现未与层粘连蛋白和胶原蛋白等其他细胞外基质成分结合的未成熟Erfibs，这表明CNS为病毒入侵触发的免疫通讯创造了独特的导管系统。

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