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Dopaminergic Circuitry Underlying Mating Drive

机译：配合驱动下的多巴胺能回路

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摘要

We develop a new system for studying how innate drives are tuned to reflect current physiological needs and capacities, and how they affect sensory-motor processing. We demonstrate the existence of male mating drive in Drosophila, which is transiently and cumulatively reduced as reproductive capacity is depleted by copulations. Dopaminergic activity in the anterior of the superior medial protocerebrum (SMPa) is also transiently and cumulatively reduced in response to matings and serves as a functional neuronal correlate of mating drive. The dopamine signal is transmitted through the D1-like DopR2 receptor to P1 neurons, which also integrate sensory information relevant to the perception of females, and which project to courtship motor centers that initiate and maintain courtship behavior. Mating drive therefore converges with sensory information from the female at the point of transition to motor output, controlling the propensity of a sensory percept to trigger goal-directed behavior.
机译：我们开发了一个新系统，用于研究先天性驱动器如何调整以反映当前的生理需求和容量，以及它们如何影响感觉运动处理。我们证明了果蝇中雄性交配驱动器的存在，由于繁殖力被交配所消耗，因此暂时和累计减少。响应于交配，上内侧前脑（SMPa）的前部的多巴胺能活性也暂时和累积降低，并用作交配驱动的功能神经元。多巴胺信号通过类似D1的DopR2受体传递到P1神经元，P1神经元还整合了与女性感知有关的感觉信息，并投射到求爱运动中心，这些运动中心开始并维持求爱行为。因此，交配驱动会在转换到电机输出时与来自雌性的感官信息融合，从而控制感官感知触发目标行为的倾向。

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