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首页> 外文期刊>Neuron >Population-Level Representation of a Temporal Sequence Underlying Song Production in the Zebra Finch
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Population-Level Representation of a Temporal Sequence Underlying Song Production in the Zebra Finch

机译：斑马雀科中歌曲产生背后的时间序列的人口水平表示

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The zebra finch brain features a set of clearly defined and hierarchically arranged motor nuclei that are selectively responsible for producing singing behavior. One of these regions, a critical forebrain structure called HVC, contains premotor neurons that are active at precise time points during song production. However, the neural representation of this behavior at a population level remains elusive. We used two-photon microscopy to monitor ensemble activity during singing, integrating across multiple trials by adopting a Bayesian inference approach to more precisely estimate burst timing. Additionally, we examined spiking and motor-related synaptic inputs using intracellular recordings during singing. With both experimental approaches, we find that premotor events do not occur preferentially at the onsets or offsets of song syllables or at specific subsyllabic motor landmarks. These results strongly support the notion that HVC projection neurons collectively exhibit a temporal sequence during singing that is uncoupled from ongoing movements.
机译：斑马雀科的大脑具有一组明确定义和层次排列的运动核，这些运动核选择性地负责产生歌唱行为。这些区域之一是称为HVC的关键前脑结构，其中包含运动前神经元，这些神经元在歌曲制作过程中的准确时间点处于活动状态。然而，在人群水平上这种行为的神经表示仍然难以捉摸。我们使用双光子显微镜来监测歌唱过程中的合奏活动，并采用贝叶斯推断方法更精确地估算爆发时间，从而整合了多个试验。此外，我们在唱歌过程中使用细胞内录音检查了突触和运动相关的突触输入。通过这两种实验方法，我们发现运动前事件不会优先出现在歌曲音节的开始或偏移处或特定的亚音节运动界标处。这些结果有力地支持了HVC投射神经元在演唱过程中总体上表现出与正在进行的运动无关的时间序列的观点。

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