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首页> 外文期刊>Neuron >Synaptic vesicle pools at the frog neuromuscular junction.
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Synaptic vesicle pools at the frog neuromuscular junction.

机译：青蛙神经肌肉接头处的突触小泡池。

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We have characterized the morphological and functional properties of the readily releasable pool (RRP) and the reserve pool of synaptic vesicles in frog motor nerve terminals using fluorescence microscopy, electron microscopy, and electrophysiology. At rest, about 20% of vesicles reside in the RRP, which is depleted in about 10 s by high-frequency nerve stimulation (30 Hz); the RRP refills in about 1 min, and surprisingly, refilling occurs almost entirely by recycling, not mobilization from the reserve pool. The reserve pool is depleted during 30 Hz stimulation with a time constant of about 40 s, and it refills slowly (half-time about 8 min) as nascent vesicles bud from randomly distributed cisternae and surface membrane infoldings and enter vesicle clusters spaced at regular intervals along the terminal. Transmitter output during low-frequency stimulation (2-5 Hz) is maintained entirely by RRP recycling; few if any vesicles are mobilized from the reserve pool.
机译：我们已经表征了使用荧光显微镜，电子显微镜和电生理学在青蛙运动神经末梢的易释放池（RRP）和突触小泡的储备池的形态和功能特性。静止时，约20％的囊泡驻留在RRP中，RRP在约10 s内被高频神经刺激（30 Hz）消耗掉。 RRP会在大约1分钟内重新填充，令人惊讶的是，重新填充几乎完全是通过回收来实现的，而不是从储备库中调动。储备池在30 Hz刺激期间以约40 s的时间常数耗尽，并且随着新生的囊泡从随机分布的水箱和表面膜折叠中萌芽并缓慢进入（以规则间隔排列）囊泡簇，其缓慢填充（约半分钟，约8分钟）沿着码头。低频激励（2-5 Hz）期间的发射机输出完全通过RRP回收来保持;从储备池中动员的囊泡很少（如果有的话）。

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