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首页> 外文期刊>Neuron >Visual stimulation is required for refinement of ON and OFF pathways in postnatal retina.
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Visual stimulation is required for refinement of ON and OFF pathways in postnatal retina.

机译:需要视觉刺激来完善产后视网膜的ON和OFF通路。

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摘要

ON and OFF pathways separately relay increment and decrement luminance signals from retinal bipolar cells to cortex. ON-OFF retinal ganglion cells (RGCs) are activated via synaptic inputs onto bistratified dendrites localized in the ON and OFF regions of the inner plexiform layer. Postnatal maturational processes convert bistratifying ON-OFF RGCs to monostratifying ON and OFF RGCs. Although visual deprivation influences refinement of higher visual centers, no previous studies suggest that light regulates either the development of the visual-evoked signaling in retinal ON and OFF pathways, nor pruning of bistratified RGC dendrites. We find that dark rearing blocks both the maturational loss of ON-OFF responsive RGCs and the pruning of dendrites. Thus, in retina, there is a previously unrecognized, pathway-specific maturation that is profoundly affected by visual deprivation.
机译:ON和OFF路径分别将增量和递减的亮度信号从视网膜双极细胞传递到皮层。通过突触输入将ON-OFF视网膜神经节细胞(RGC)激活到位于内部丛状层的ON和OFF区域中的双分层树突上。产后成熟过程将双分层的ON-OFF RGC转换为单分层的ON和OFF RGC。尽管视觉剥夺会影响较高视力中心的精细化,但先前的研究均未表明光调节视网膜ON和OFF通路中视觉诱发信号的发育,也不会调节双层RGC树突的修剪。我们发现,黑暗饲养既阻止了ON-OFF响应RGC的成熟损失,又阻止了树突的修剪。因此,在视网膜中,存在先前未被识别的,特定于途径的成熟,其受到视觉剥夺的深刻影响。

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