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首页> 外文期刊>Neuron >Activation of a tyrosine kinase-MAPK cascade enhances the induction of long-term synaptic facilitation and long-term memory in Aplysia.
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Activation of a tyrosine kinase-MAPK cascade enhances the induction of long-term synaptic facilitation and long-term memory in Aplysia.

机译：酪氨酸激酶-MAPK级联的激活增强了海藻中长期突触促进和长期记忆的诱导。

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摘要

Tyrosine kinases have been implicated in cellular processes thought to underlie learning and memory. Here we show that tyrosine kinases play a direct role in long-term synaptic facilitation (LTF) and long-term memory (LTM) for sensitization in Aplysia. Tyrosine kinase activity is required for serotonin-induced LTF of sensorimotor (SN-MN) synapses, and enhancement of endogenous tyrosine kinase activity facilitates the induction of LTF. These effects are mediated, at least in part, through mitogen-activated protein kinase (MAPK) activation and are blocked by transcriptional and translational inhibitors. Moreover, brain-derived neurotrophic factor (BDNF) also enhances the induction of LTF in a MAPK-dependent fashion. Finally, activation of endogenous tyrosine kinases enhances the induction of long-term memory for sensitization, and this enhancement also requires MAPK activation. Thus, tyrosine kinases, acting through MAPK, play a pivotal role in LTF and LTM formation.
机译：酪氨酸激酶与认为是学习和记忆基础的细胞过程有关。在这里，我们显示酪氨酸激酶在海藻中致敏的长期突触促进（LTF）和长期记忆（LTM）中起直接作用。血清素诱导的感觉运动（SN-MN）突触的LTF需要酪氨酸激酶活性，内源性酪氨酸激酶活性的增强促进LTF的诱导。这些作用至少部分地通过有丝分裂原激活的蛋白激酶（MAPK）激活介导，并被转录和翻译抑制剂所阻断。此外，脑源性神经营养因子（BDNF）还以MAPK依赖性方式增强LTF的诱导。最后，内源性酪氨酸激酶的激活增强了对致敏作用的长期记忆的诱导，并且这种增强还需要MAPK激活。因此，通过MAPK起作用的酪氨酸激酶在LTF和LTM形成中起关键作用。

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