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首页> 外文期刊>Neuron >A specialized subclass of interneurons mediates dopaminergic facilitation of amygdala function.
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A specialized subclass of interneurons mediates dopaminergic facilitation of amygdala function.

机译：中间神经元的专门子类介导杏仁核功能的多巴胺能促进。

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The amygdala is under inhibitory control from the cortex through the activation of local GABAergic interneurons. This inhibition is greatly diminished during heightened emotional states due to dopamine release. However, dopamine excites most amygdala interneurons, suggesting that this dopaminergic gate may be mediated by an unknown subpopulation of interneurons. We hypothesized that this gate is mediated by paracapsular intercalated cells, a subset of interneurons that are innervated by both cortical and mesolimbic dopaminergic afferents. Using transgenic mice that express GFP in GABAergic interneurons, we show that paracapsular cells form a network surrounding the basolateral complex of the amygdala. We found that they provide feedforward inhibition into the basolateral and the central amygdala. Dopamine hyperpolarized paracapsular cells through D1 receptors and substantially suppressed their excitability, resulting in a disinhibition of the basolateral and central nuclei. Suppression of the paracapsular system by dopamine provides a compelling neural mechanism for the increased affective behavior observed during stress or other hyperdopaminergic states.
机译：杏仁核通过局部GABA能中间神经元的激活而受到来自皮质的抑制控制。由于多巴胺释放，在情绪高涨时，这种抑制作用会大大降低。然而，多巴胺能激发大多数杏仁核中间神经元，表明该多巴胺能门可能是由未知的中间神经元亚群介导的。我们假设该门由囊旁插层细胞介导，这是由皮层和中脑边缘多巴胺能传入神经支配的interneurons的子集。使用在GABA能性神经元中表达GFP的转基因小鼠，我们显示了囊旁细胞形成围绕杏仁核基底外侧复合物的网络。我们发现，它们对基底外侧和中央杏仁核提供前馈抑制作用。多巴胺会通过D1受体使极化的超囊化细胞过度极化，并显着抑制其兴奋性，从而导致基底外侧核和中枢核的抑制作用。多巴胺对囊旁系统的抑制为在应激或其他高多巴胺能状态下观察到的情感行为增加提供了令人信服的神经机制。

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