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首页> 外文期刊>Neuron >Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6.
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Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6.

机译：后脑菱形唇由Pax6分配的离散祖细胞群组成。

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摘要

The lower rhombic lip (LRL) is a germinal zone in the dorsal hindbrain productive of tangentially migrating neurons, streaming extramurally (mossy fiber neurons) or intramurally (climbing fiber neurons). Here we show that LRL territory, operationally defined by Wnt1 expression, is parceled into molecular subdomains predictive of cell fate. Progressing dorsoventrally, Lmx1a and Gdf7 expression identifies the primordium for hindbrain choroid plexus epithelial cells; Math1, for mossy fiber neurons; and immediately ventral to Math1 yet within Wnt1(+) territory, a climbing fiber primordium dominated by Ngn1-expressing cells. Elimination of Pax6 results in expansion of this Ngn1(+) progenitor pool and reduction in the Math1(+) pool, with accompanying later enlargement of the climbing fiber nucleus and reductions in mossy fiber nuclei. Pax6 loss also disrupts Msx expression cell-nonautonomously, suggesting Pax6 may influence LRL progenitor identity indirectly through potentiating BMP signaling. These studies suggest that underlying the diversity and proportions of fates produced by the LRL is a precise suborganization regulated by Pax6.
机译：下菱形唇（LRL）是背后脑的生发区，产生切向迁移的神经元，在神经外流（苔藓纤维神经元）或在胃内流（爬纤维神经元）。在这里，我们显示了由Wnt1表达可操作定义的LRL区域，被包裹到预测细胞命运的分子亚域中。 Lmx1a和Gdf7的表达在背腹进展，可识别后脑脉络丛神经上皮细胞的原基。 Math1，用于生苔纤维神经元;并立即到达Wnt1（+）区域内的Math1腹侧，这是一个由表达Ngn1的细胞主导的攀登纤维原基。消除Pax6会导致此Ngn1（+）祖细胞池扩大，而Math1（+）池细胞减少，随之而来的是攀爬纤维核的扩大和苔藓纤维核的减少。 Pax6丢失也会非自主地破坏Msx表达，这表明Pax6可能通过增强BMP信号传导间接影响LRL祖细胞的身份。这些研究表明，LRL产生的命运的多样性和比例的根本是受Pax6调控的精确亚组织。

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