GABA excitation in the adult brain: a mechanism for excitation- neurogenesis coupling.

Deisseroth K; Malenka RC

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GABA excitation in the adult brain: a mechanism for excitation- neurogenesis coupling.

机译：成年大脑中的GABA激发：激发神经发生耦合的机制。

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The production of new neurons in the adult hippocampus is exquisitely regulated, and alterations in this process may underlie both normal and pathological hippocampal function. In this issue of Neuron, Tozuka et al. describe electrophysiological recordings that target proliferating progenitor cells in adult mouse hippocampal slices. They report that GABAergic synaptic inputs directly depolarize the proliferating progenitors, thereby activating molecular players that favor neuronal differentiation and providing a mechanism for direct excitation-neurogenesis coupling in vivo.

机译：成年海马中新神经元的产生受到严格的调节，这一过程的改变可能是正常和病理性海马功能的基础。在本期《神经元》中，Tozuka等人。描述了针对成年小鼠海马切片中增殖祖细胞的电生理记录。他们报告说，GABA能突触输入直接使增殖祖细胞去极化，从而激活有利于神经元分化的分子，并提供了体内直接激发-神经发生偶联的机制。

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《Neuron》 |2005年第6期|共3页
作者
Deisseroth K; Malenka RC;
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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Adult; neurogenesis; gamma-Aminobutyric Acid; Brain; differentiation; 成年人; 脑;

机译：Adult;neurogenesis;gamma-Aminobutyric Acid;Brain;differentiation;成年人;脑;

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1. GABA excitation in the adult brain: a mechanism for excitation- neurogenesis coupling. [J] . Deisseroth K, Malenka RC Neuron . 2005,第6期

机译：成年大脑中的GABA激发：激发神经发生耦合的机制。
2. Mechanisms of cell migration in the adult brain: modelling subventricular neurogenesis [J] . A. Van Schepdael, J.M.A. Ashbourn, R. Beard, Computer methods in biomechanics and biomedical engineering . 2013,第10a12期

机译：成年大脑中细胞迁移的机制：模拟脑室下神经发生。
3. Mechanisms mediating brain plasticity: IGF1 and adult hippocampal neurogenesis. [J] . Llorens Martin M, Torres Aleman I, Trejo JL The Neuroscientist: a review journal bringing neurobiology, neurology and psychiatry . 2009,第2期

机译：介导大脑可塑性的机制：IGF1和成人海马神经发生。
4. Mechanisms and functions of neurogenesis in the limbic system of adult animals [C] . Tatyana Zapara, Alexander Romashchenko, Anna Proskura, Conference on Cognitive Sciences, Genomics and Bioinformatics . 2020

机译：成年动物边缘系统中神经发生的机制和功能
5. Using Zebrafish to Elucidate the Epigenetic Mechanisms Controlling Neurogenesis and Brain Tumorigenesis [D] . Schultz, Laura Elizabeth. 2018

机译：使用斑马鱼阐明控制神经发生和脑肿瘤发生的表观遗传机制。
6. Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis [O] . Christina Catavero, Hechen Bao, Juan Song -1

机译：GABA能调节成年海马神经发生的神经机制
7. GABA Excitation in the Adult Brain: A Mechanism for Excitation- Neurogenesis Coupling [O] . Deisseroth Karl, Malenka Robert C. 2005

机译：成年大脑中的GABA激发：激发-神经发生耦合的机制。

GABA excitation in the adult brain: a mechanism for excitation- neurogenesis coupling.

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