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首页> 外文期刊>Neuron >Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.
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Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.

机译：神经肽FF和FMRFamide增强了来自感觉神经元和质子门控DEG / ENaC通道的酸诱发电流。

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摘要

Acidosis is associated with inflammation and ischemia and activates cation channels in sensory neurons. Inflammation also induces expression of FMRFamidelike neuropeptides, which modulate pain. We found that neuropeptide FF (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide) and FMRFamide (Phe-Met-Arg-Phe amide) generated no current on their own but potentiated H+-gated currents from cultured sensory neurons and heterologously expressed ASIC and DRASIC channels. The neuropeptides slowed inactivation and induced sustained currents during acidification. The effects were specific; different channels showed distinct responses to the various peptides. These results suggest that acid-sensing ion channels may integrate multiple extracellular signals to modify sensory perception.
机译：酸中毒与炎症和局部缺血有关，并激活感觉神经元中的阳离子通道。炎症也诱导调理FMRFamidelike神经肽的表达。我们发现神经肽FF（Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe酰胺）和FMRFamide（Phe-Met-Arg-Phe酰胺）自身未产生电流，但通过培养的感觉产生了增强的H +门控电流神经元和异源表达的ASIC和DRASIC通道。在酸化过程中，神经肽减缓了失活并诱导了持续的电流。效果是特定的;不同的通道显示出对各种肽的不同反应。这些结果表明，酸敏感离子通道可能整合了多个细胞外信号，以改变感觉。

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