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首页> 外文期刊>Neuron >Ca2+-induced Ca2+ release supports the relay mode of activity in thalamocortical cells.
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Ca2+-induced Ca2+ release supports the relay mode of activity in thalamocortical cells.

机译：Ca2 +诱导的Ca2 +释放支持丘脑皮层细胞的中继活动模式。

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摘要

Ca2+ ions play an important role during rhythmic bursting of thalamocortical neurons within sleep. The function of Ca2+ during the tonic relay mode of these neurons during wakefulness is less clear. Here, we report that tonic activity in thalamocortical cells results in an increase in the intracellular Ca2+ concentration and subsequent release of Ca2+ from intracellular stores mediated via ryanodine receptors (RyRs). Blockade of Ca2+ release shifted the regular firing of single action potentials toward the generation of spike clusters. Regular spike firing and intracellular Ca2+ release thus appear to be functionally coupled in a positive feedback manner, thereby supporting the relay mode of thalamocortical cells during wakefulness. Regulatory influences may be coupled to this system via the cyclic ADP ribose pathway.
机译：Ca2 +离子在睡眠中丘脑皮质神经元的节律性爆发中起重要作用。在清醒期间这些神经元的强音中继模式中Ca2 +的功能尚不清楚。在这里，我们报道丘脑皮层细胞的滋补活性导致细胞内Ca2 +浓度增加，以及随后通过ryanodine受体（RyRs）介导的细胞内Ca2 +释放。 Ca 2+释放的阻滞使单动作电位的正常发射向尖峰簇的产生转移。因此，正常的穗发射和细胞内Ca 2+释放似乎以正反馈的方式在功能上耦合，从而支持清醒期间丘脑皮层细胞的中继模式。调节作用可通过环状ADP核糖途径偶联至该系统。

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