...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis.
【24h】

NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis.

机译：NRAGE是一种新型MAGE蛋白，可与p75神经营养蛋白受体相互作用，并促进神经生长因子依赖性细胞凋亡。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The mechanisms employed by the p75 neurotrophin receptor (p75NTR) to mediate neurotrophin-dependent apoptosis are poorly defined. Two-hybrid analyses were used to identify proteins involved in p75NTR apoptotic signaling, and a p75NTR binding partner termed NRAGE (for neurotrophin receptor-interacting MAGE homolog) was identified. NRAGE binds p75NTR in vitro and in vivo, and NRAGE associates with the plasma membrane when NGF is bound to p75NTR. NRAGE blocks the physical association of p75NTR with TrkA, and, conversely, TrkA overexpression eliminates NRAGE-mediated NGF-dependent death, indicating that interactions of NRAGE or TrkA with p75NTR are functionally and physically exclusive. NRAGE overexpression facilitates cell cycle arrest and permits NGF-dependent apoptosis within sympathetic neuron precursors cells. Our results show that NRAGE contributes to p75NTR-dependent cell death and suggest novel functions for MAGE family proteins.
机译：p75神经营养蛋白受体（p75NTR）介导神经营养蛋白依赖性细胞凋亡所采用的机制尚不清楚。使用两次杂交分析来鉴定参与p75NTR细胞凋亡信号传导的蛋白，并鉴定出一个称为NRAGE（用于与神经营养蛋白受体相互作用的MAGE同源物）的p75NTR结合伴侣。 NRAGE在体外和体内均与p75NTR结合，当NGF与p75NTR结合时，NRAGE与质膜结合。 NRAGE阻断了p75NTR与TrkA的物理联系，相反，TrkA过表达消除了NRAGE介导的NGF依赖性死亡，表明NRAGE或TrkA与p75NTR的相互作用在功能和物理上都是排他的。 NRAGE过表达促进细胞周期停滞并允许交感神经元前体细胞内依赖NGF的细胞凋亡。我们的结果表明NRAGE有助于p75NTR依赖的细胞死亡，并暗示MAGE家族蛋白的新功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号