Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice.

Gillespie CS; Sherman DL; Fleetwood Walker-SM; Cottrell DF; Tait S; Garry EM; Wallace VC; Ure J; Griffiths IR; Smith A; Brophy PJ

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Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice.

机译：Periaxin缺陷小鼠的周围脱髓鞘和神经性疼痛行为。

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The Prx gene in Schwann cells encodes L- and S-periaxin, two abundant PDZ domain proteins thought to have a role in the stabilization of myelin in the peripheral nervous system (PNS). Mice lacking a functional Prx gene assemble compact PNS myelin. However, the sheath is unstable, leading to demyelination and reflex behaviors that are associated with the painful conditions caused by peripheral nerve damage. Older Prx-/- animals display extensive peripheral demyelination and a severe clinical phenotype with mechanical allodynia and thermal hyperalgesia, which can be reversed by intrathecal administration of a selective NMDA receptor antagonist We conclude that the periaxins play an essential role in stabilizing the Schwann cell-axon unit and that the periaxin-deficient mouse will be an important model for studying neuropathic pain in late onset demyelinating disease.

机译：Schwann细胞中的Prx基因编码L-和S-periaxin，这是两种丰富的PDZ域蛋白，被认为对稳定周围神经系统（PNS）中的髓磷脂具有作用。缺乏功能性Prx基因的小鼠组装紧凑的PNS髓磷脂。但是，护套不稳定，导致脱髓鞘和反射行为，与周围神经损伤引起的疼痛状况有关。较老的Prx-/-动物表现出广泛的外周脱髓鞘和严重的临床表型，并伴有机械性异常性疼痛和热痛觉过敏，可以通过鞘内注射选择性NMDA受体拮抗剂来逆转。轴突单位和periaxin缺陷小鼠将是研究迟发性脱髓鞘疾病的神经性疼痛的重要模型。

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《Neuron》 |2000年第2期|共9页
作者
Gillespie CS; Sherman DL; Fleetwood Walker-SM; Cottrell DF; Tait S; Garry EM; Wallace VC; Ure J; Griffiths IR; Smith A; Brophy PJ;
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正文语种 eng
中图分类神经生理学;
关键词
Behavior; Animal; Demyelinating Diseases; Membrane Proteins; Pain; Peripheral Nervous System Diseases; 行为; 动物; 脱髓鞘疾病; 膜蛋白质类; 疼痛; 周围神经系统疾病;

机译：Behavior;Animal;Demyelinating Diseases;Membrane Proteins;Pain;Peripheral Nervous System Diseases;行为;动物;脱髓鞘疾病;膜蛋白质类;疼痛;周围神经系统疾病;

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专利

1. Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice. [J] . Gillespie CS, Sherman DL, Fleetwood Walker-SM, Neuron . 2000,第2期

机译：Periaxin缺陷小鼠的周围脱髓鞘和神经性疼痛行为。
2. Erythropoietin reduces nerve demyelination, neuropathic pain behavior and microglial MAPKs activation through erythropoietin receptors on Schwann cells in a rat model of peripheral neuropathy [J] . Huang Chun-Ta, Chen Seu-Hwa, Lin Shih-Chang, Glia . 2018,第11期

机译：促红细胞生成素受体在外周神经病变大鼠模型中通过梭菌细胞的促红农素受体减少神经脱髓鞘，神经性疼痛行为和微痛Mapks活化
3. Focal lysolecithin-induced demyelination of peripheral afferents results in neuropathic pain behavior that is attenuated by cannabinoids. [J] . Wallace VC, Cottrell DF, Brophy PJ, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2003,第8期

机译：局部溶血卵磷脂诱导的外周传入神经脱髓鞘导致神经性疼痛行为，其被大麻素减轻。
4. Efective adjuvant treatment of neuropathic pain in peripheral neuropathy by acupuncture [C] . Schroeder S, Epplee S International Congress on Neuropathic Pain . 2010

机译：针刺治疗周围神经病变神经性疼痛的有效辅助治疗
5. Peripheral and spinal mechanisms of neuropathic behaviors following peripheral nerve injury. [D] . Wagner, Rochelle. 1995

机译：周围神经损伤后神经病变行为的周围和脊髓机制。
6. Focal Lysolecithin-Induced Demyelination of Peripheral Afferents Results in Neuropathic Pain Behavior That Is Attenuated by Cannabinoids [O] . Victoria C. J. Wallace, David F. Cottrell, Peter J. Brophy, 2003

机译：局灶性溶血卵磷脂诱导的外周传入脱髓鞘导致大麻素减轻的神经性疼痛行为。
7. Peripheral Demyelination and Neuropathic Pain Behavior in Periaxin-Deficient Mice [O] . Gillespie C.Stewart, Sherman Diane L., Fleetwood-Walker Susan M., 2000

机译：Periaxin缺陷小鼠的外周脱髓鞘和神经性疼痛行为

Peripheral demyelination and neuropathic pain behavior in periaxin-deficient mice.

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