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首页> 外文期刊>Neuron >The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C.
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The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C.

机译：通过其对磷脂酶C的影响，光转导需要SOCS盒蛋白STOPS。

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摘要

Phosphoinositide-specific phospholipase C (PLC) isozymes play roles in a diversity of processes including Drosophila phototransduction. In fly photoreceptor cells, the PLCbeta encoded by norpA is critical for activation of TRP channels. Here, we describe a PLCbeta regulator, STOPS, which encodes a SOCS box protein. Mutation of stops resulted in a reduced concentration of NORPA and a defect in stopping signaling following cessation of the light stimulus. NORPA has been proposed to have dual roles as a PLC- and GTPase-activating protein (GAP). We found that the slow termination resulting from expressing low levels of wild-type NORPA was suppressed by addition of normal amounts of an altered NORPA, which had wild-type GAP activity, but no PLC activity. STOPS is the first protein identified that specifically regulates PLCbeta protein concentration. Moreover, this work demonstrates that a PLCbeta derivative that does not promote TRP channel activation, still contributes to signaling in vivo.
机译：磷脂酰肌醇特异性磷脂酶C（PLC）同工酶在果蝇光转导等多种过程中发挥作用。在飞行的感光细胞中，由norpA编码的PLCbeta对于激活TRP通道至关重要。在这里，我们描述了一个PLCbeta调节器STOPS，它编码SOCS盒蛋白。终止的突变导致NORPA的浓度降低，并且在停止光刺激后终止信号传导中的缺陷。已经提出NORPA具有PLC和GTP酶激活蛋白（GAP）的双重作用。我们发现，通过表达正常水平的具有野生型GAP活性但无PLC活性的改变的NORPA，可以抑制由于表达低水平的野生型NORPA而导致的缓慢终止。 STOPS是鉴定出的第一个特异性调节PLCbeta蛋白浓度的蛋白。此外，这项工作表明，不促进TRP通道激活的PLCbeta衍生物仍有助于体内信号传导。

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