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首页> 外文期刊>Neuron >SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning.
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SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning.

机译：SynCAM 1粘附力可动态调节突触数量，并影响可塑性和学习能力。

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摘要

Synaptogenesis is required for wiring neuronal circuits in the developing brain and continues to remodel adult networks. However, the molecules organizing synapse development and maintenance in vivo remain incompletely understood. We now demonstrate that the immunoglobulin adhesion molecule SynCAM 1 dynamically alters synapse number and plasticity. Overexpression of SynCAM 1 in transgenic mice promotes excitatory synapse number, while loss of SynCAM 1 results in fewer excitatory synapses. By turning off SynCAM 1 overexpression in transgenic brains, we show that it maintains the newly induced synapses. SynCAM 1 also functions at mature synapses to alter their plasticity by regulating long-term depression. Consistent with these effects on neuronal connectivity, SynCAM 1 expression affects spatial learning, with knock-out mice learning better. The reciprocal effects of increased SynCAM 1 expression and loss reveal that this adhesion molecule contributes to the regulation of synapse number and plasticity, and impacts how neuronal networks undergo activity-dependent changes.
机译：突触发生是在发育中的大脑中布线神经元回路所必需的，并且继续重塑成人网络。然而，在体内组织突触发展和维持的分子仍未完全了解。现在我们证明免疫球蛋白粘附分子SynCAM 1动态改变突触的数目和可塑性。 SynCAM 1在转基因小鼠中的过表达促进了兴奋性突触的数量，而SynCAM 1的丢失导致较少的兴奋性突触。通过关闭转基因大脑中的SynCAM 1过表达，我们表明它维持了新诱导的突触。 SynCAM 1在成熟的突触中也起作用，通过调节长期抑郁来改变其可塑性。与这些对神经元连接性的影响一致，SynCAM 1表达影响空间学习，而剔除小鼠的学习效果更好。增加的SynCAM 1表达和损失的相互影响表明，该粘附分子有助于突触数量和可塑性的调节，并影响神经元网络如何进行活动依赖性变化。

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