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首页> 外文期刊>Neuron >Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions.
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Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions.

机译：果蝇神经胶蛋白1促进谷氨酸能神经肌肉连接处的生长和突触后分化。

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摘要

Precise apposition of presynaptic and postsynaptic domains is a fundamental property of all neuronal circuits. Experiments in vitro suggest that Neuroligins and Neurexins function as key regulatory proteins in this process. In a genetic screen, we recovered several mutant alleles of Drosophila neuroligin 1 (dnlg1) that cause a severe reduction in bouton numbers at neuromuscular junctions (NMJs). In accord with reduced synapse numbers, these NMJs show reduced synaptic transmission. Moreover, lack of postsynaptic DNlg1 leads to deficits in the accumulation of postsynaptic glutamate receptors, scaffold proteins, and subsynaptic membranes, while increased DNlg1 triggers ectopic postsynaptic differentiation via its cytoplasmic domain. DNlg1 forms discrete clusters adjacent to postsynaptic densities. Formation of these clusters depends on presynaptic Drosophila Neurexin (DNrx). However, DNrx binding is not an absolute requirement for DNlg1 function. Instead, other signaling components are likely involved in DNlg1 transsynaptic functions, with essential interactions organized by the DNlg1 extracellular domain but also by the cytoplasmic domain.
机译：突触前和突触后域的精确并置是所有神经元回路的基本属性。体外实验表明，神经胶蛋白和神经毒素在此过程中起关键调节蛋白的作用。在遗传筛选中，我们回收了果蝇神经胶蛋白1（dnlg1）的几个突变等位基因，这些突变等位基因导致神经肌肉接头（NMJs）的胸肉数量严重减少。与减少的突触数量一致，这些NMJ显示出减少的突触传递。此外，缺乏突触后DNlg1会导致突触后谷氨酸受体，支架蛋白和突触膜的积累不足，而增加的DNlg1则通过其胞质结构域触发异位突触后分化。 DNlg1形成邻近突触后密度的离散簇。这些簇的形成取决于突触前的果蝇神经毒素（DNrx）。但是，DNrx绑定不是DNlg1函数的绝对要求。取而代之的是，其他信号传导组件可能参与了DNlg1的突触功能，其主要相互作用是由DNlg1细胞外结构域以及细胞质结构域组织的。

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