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首页> 外文期刊>Neuron >The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits.
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The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits.

机译：离子型谷氨酸受体的扩展社会网络：TARPs和其他跨膜辅助亚单位。

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Ionotropic glutamate receptors (iGluRs) underlie rapid, excitatory synaptic signaling throughout the CNS. After years of intense research, our picture of iGluRs has evolved from them being companionless in the postsynaptic membrane to them being the hub of dynamic supramolecular signaling complexes, interacting with an ever-expanding litany of other proteins that regulate their trafficking, scaffolding, stability, signaling, and turnover. In particular, the discovery that transmembrane AMPA receptor regulatory proteins (TARPs) are AMPA receptor auxiliary subunits that are critical determinants of their trafficking, gating, and pharmacology has changed the way we think about iGluR function. Recently, a number of novel transmembrane proteins have been uncovered that may also serve as iGluR auxiliary proteins. Here we review pivotal developments in our understanding of the role of TARPs in AMPA receptor trafficking and gating, and provide an overview of how newly discovered transmembrane proteins expand our view of iGluR function in the CNS.
机译：离子型谷氨酸受体（iGluRs）是整个CNS中快速，兴奋性突触信号的基础。经过多年的深入研究，我们对iGluR的了解已从在突触后膜上无伴侣状态演变为动态超分子信号复合体的枢纽，并与其他不断增长的调节其运输，支架，稳定性，信号和营业额。尤其是跨膜AMPA受体调节蛋白（TARP）是AMPA受体辅助亚基的发现，这是其转运，门控和药理学的关键决定因素，这一发现改变了我们对iGluR功能的思考方式。最近，发现了许多新颖的跨膜蛋白，它们也可以作为iGluR辅助蛋白。在这里，我们回顾了对TARPs在AMPA受体运输和门控中的作用的理解方面的关键发展，并概述了新发现的跨膜蛋白如何扩展我们对CNS中iGluR功能的看法。

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