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首页> 外文期刊>Neuron >Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting.
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Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting.

机译：退化的幼虫ORN轴突分泌的信号量可指导成年投射神经元树突靶向。

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摘要

During assembly of the Drosophila olfactory circuit, projection neuron (PN) dendrites prepattern the developing antennal lobe before the arrival of axons from their presynaptic partners, the adult olfactory receptor neurons (ORNs). We previously found that levels of transmembrane Semaphorin-1a, which acts as a receptor, instruct PN dendrite targeting along the dorsolateral-ventromedial axis. Here we show that two secreted semaphorins, Sema-2a and Sema-2b, provide spatial cues for PN dendrite targeting. Sema-2a and Sema-2b proteins are distributed in gradients opposing the Sema-1a protein gradient, and Sema-1a binds to Sema-2a-expressing cells. In Sema-2a and Sema-2b double mutants, PN dendrites that normally target dorsolaterally in the antennal lobe mistarget ventromedially, phenocopying cell-autonomous Sema-1a removal from these PNs. Cell ablation, cell-specific knockdown, and rescue experiments indicate that secreted semaphorins from degenerating larval ORN axons direct dendrite targeting. Thus, a degenerating brain structure instructs the wiring of a developing circuit through the repulsive action of secreted semaphorins.
机译：在果蝇嗅觉回路的组装过程中，投射神经元（PN）在轴突从突触前伴侣成人嗅觉感受器神经元（ORNs）到达之前，预先形成发育中的触角叶。我们先前发现跨膜Semaphorin-1a作为受体的水平指示PN树突沿背外侧-脑室轴定向。在这里，我们显示了两个分泌的信号量，Sema-2a和Sema-2b，为PN枝晶靶向提供了空间线索。 Sema-2a和Sema-2b蛋白以与Sema-1a蛋白梯度相反的梯度分布，并且Sema-1a与表达Sema-2a的细胞结合。在Sema-2a和Sema-2b双重突变体中，通常在触角背侧靶向PN的树突向腹侧靶向，将这些PN中的细胞自主性Sema-1a移出表型。细胞消融，细胞特异性敲低和拯救实验表明，来自退化幼虫ORN轴突的分泌信号量可直接靶向树突。因此，退化的大脑结构通过分泌的信号量的排斥作用指示显影电路的布线。

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