ADAM10 prodomain mutations cause late-onset alzheimer's disease: Not just the latest FAD

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ADAM10 prodomain mutations cause late-onset alzheimer's disease: Not just the latest FAD

机译：ADAM10前结构域突变会导致晚期阿尔茨海默氏病：不仅仅是最新的FAD

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In this issue of Neuron, Suh etal. (2013) describe two rare ADAM10 prodomain mutations that cause late-onset Alzheimer's disease by impairing prodomain chaperone function, attenuating α-secretase activity, and reducing adult hippocampal neurogenesis. These results support both ADAM10 as a therapeutic target and the amyloid hypothesis of Alzheimer's disease.

机译：在《神经元》杂志上，Suh等人。（2013）描述了两个罕见的ADAM10前结构域突变，它们通过破坏前结构域伴侣功能，减弱α-分泌酶活性并减少成年海马神经发生而引起迟发性阿尔茨海默氏病。这些结果支持ADAM10作为治疗靶标和阿尔茨海默氏病的淀粉样假说。

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《Neuron》 |2013年第2期|共4页
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1. ADAM10 prodomain mutations cause late-onset alzheimer's disease: Not just the latest FAD [J] . VassarR. Neuron . 2013,第2期

机译：ADAM10前结构域突变会导致晚期阿尔茨海默氏病：不仅仅是最新的FAD
2. Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. [J] . Kim M, Suh J, Romano D Human Molecular Genetics . 2009,第20期

机译：ADAM10基因中潜在的迟发性早老性痴呆症相关突变会减弱α-分泌酶的活性。
3. Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity [J] . Minji Kim1 Jaehong Suh1 Donna Romano1 Mimy H. Truong1 Kristina Mullin1 Basavaraj Hooli1 David Norton1 Giuseppina Tesco1 Kathy Elliott2 Steven L. Wagner2 Robert D. Moir1 K. David Becker2 and Rudolph E. Tanzi1* Human Molecular Genetics . 2009,第20期

机译：ADAM10基因中潜在的迟发性早老性痴呆症相关突变会减弱α-分泌酶的活性
4. ADAM10 and alzheimer's disease: a study with brazilian elderly [C] . Manzine P.R. Araújo H.S.S., Vale F.A.C., Barham E.J., International Conference of Alzheimer's Disease International . 2012

机译：Adam10和Alzheimer的疾病：与巴西老年人的一项研究
5. Investigation of genetic susceptibility to late-onset Alzheimer disease through genomic convergence. [D] . Liang, Xueying. 2007

机译：通过基因组收敛研究迟发性阿尔茨海默病的遗传易感性。
6. ADAM10 Prodomain Mutations Cause Late-Onset Alzheimer’sDisease: Not Just the Latest FAD [O] . Robert Vassar -1

机译：ADAM10前域突变会导致晚期阿尔茨海默氏病疾病：不仅仅是最新的FAD
7. ADAM10 Prodomain Mutations Cause Late-Onset Alzheimer’s Disease: Not Just the Latest FAD [O] . Vassar Robert 2013

机译：ADAM10前结构域突变会导致晚期阿尔茨海默氏病：不仅是最新的FAD

ADAM10 prodomain mutations cause late-onset alzheimer's disease: Not just the latest FAD

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