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A biophysically detailed model of neocortical local field potentials predicts the critical role of active membrane currents

机译：新皮层局部场电位的生物物理学详细模型预测了活性膜电流的关键作用

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Brain activity generates extracellular voltage fluctuations recorded as local field potentials (LFPs). It is known that the relevant microvariables, the ionic currents across membranes, jointly generate the macrovariables, the extracellular voltage, but neither the detailed biophysical knowledge nor the required computational power have been available to model these processes. We simulated the LFP in a model of the rodent neocortical column composed of >12,000 reconstructed, multicompartmental, and spiking cortical layer 4 and 5 pyramidal neurons and basket cells, including five million dendritic and somatic compartments with voltage- and ion-dependent currents, realistic connectivity, and probabilistic AMPA, NMDA, and GABA synapses. We found that, depending on a number of factors, the LFP reflects local and cross-layer processing. Active currents dominate the generation of LFPs, not synaptic ones. Spike-related currents impact the LFP not only at higher frequencies but below 50Hz. This work calls for re-evaluating the genesis of LFPs.
机译：脑部活动产生细胞外电压波动，记录为局部电场电位（LFP）。众所周知，相关的微变量，即跨膜的离子流，共同产生了宏变量，即细胞外电压，但是尚无详细的生物物理知识或所需的计算能力来模拟这些过程。我们在啮齿动物新皮质柱模型中模拟了LFP，该模型由> 12,000个重构的，多隔室和尖刺的皮质第4层和第5层锥体神经元和篮状细胞组成，其中包括500万个具有电压和离子依赖性电流的树突和体室连接性和概率AMPA，NMDA和GABA突触。我们发现，取决于许多因素，LFP反映了本地和跨层处理。有功电流支配着LFP的产生，而不是突触的产生。与峰值相关的电流不仅会在较高频率下而且会在50Hz以下影响LFP。这项工作要求重新评估LFP的起源。

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