Sensory neuron fates are distinguished by a transcriptional switch that regulates dendrite branch stabilization

SmithC.; OBrienT.; ChatzigeorgiouM.; ClaySpencerW.; Feingold-LinkE.; HussonS.; HoriS.; MitaniS.; GottschalkA.; SchaferW.; MillerD.

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Sensory neuron fates are distinguished by a transcriptional switch that regulates dendrite branch stabilization

机译：感觉神经元命运的特征是调节树突分支稳定的转录开关

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Sensory neurons adopt distinct morphologies and functional modalities to mediate responses to specific stimuli. Transcription factors and their downstream effectors orchestrate this outcome but are incompletely defined. Here, we show that different classes of mechanosensory neurons in C.elegans are distinguished by the combined action of the transcription factors MEC-3, AHR-1, and ZAG-1. Low levels of MEC-3 specify the elaborate branching pattern of PVD nociceptors, whereas high MEC-3 is correlated with the simple morphology of AVM and PVM touch neurons. AHR-1 specifies AVM touch neuron fate by elevating MEC-3 while simultaneously blocking expression of nociceptive genes such as the MEC-3 target, the claudin-like membrane protein HPO-30, that promotes the complex dendritic branching pattern of PVD. ZAG-1 exercises a parallel role to prevent PVM from adopting the PVD fate. The conserved dendritic branching function of the Drosophila AHR-1 homolog, Spineless, argues for similar pathways in mammals.

机译：感觉神经元采用不同的形态和功能方式来介导对特定刺激的反应。转录因子及其下游效应器协调了这一结果，但定义不完全。在这里，我们显示秀丽隐杆线虫的不同类别的机械感觉神经元的区别在于转录因子MEC-3，AHR-1和ZAG-1的联合作用。低水平的MEC-3指定了PVD伤害感受器的精细分支模式，而高水平的MEC-3与AVM和PVM触摸神经元的简单形态相关。 AHR-1通过提高MEC-3来指定AVM触摸神经元的命运，同时阻止伤害性基因（例如MEC-3靶标，类claudin膜蛋白HPO-30）的表达，从而促进PVD的复杂树突分支模式。 ZAG-1扮演着并行的角色，以防止PVM采用PVD命运。果蝇AHR-1同源物Spineless的保守树突分支功能为哺乳动物提供了类似的途径。

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《Neuron》 |2013年第2期|共15页
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SmithC.; OBrienT.; ChatzigeorgiouM.; ClaySpencerW.; Feingold-LinkE.; HussonS.; HoriS.; MitaniS.; GottschalkA.; SchaferW.; MillerD.;
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1. Sensory neuron fates are distinguished by a transcriptional switch that regulates dendrite branch stabilization [J] . SmithC., OBrienT., ChatzigeorgiouM., Neuron . 2013,第2期

机译：感觉神经元命运的特征是调节树突分支稳定的转录开关
2. FoxO regulates microtubule dynamics and polarity to promote dendrite branching in Drosophila sensory neurons [J] . James C. Sears, Heather T. Broihier Developmental biology . 2016,第1期

机译：FoxO调节微管动力学和极性，以促进果蝇感觉神经元中的树枝状分支。
3. C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. [J] . Aguirre Chen C, Bulow HE, Kaprielian Z Development . 2011,第3期

机译：线虫bicd-1，果蝇动力蛋白辅助因子Bicaudal D的同源物，调节PVD感觉神经元树突的分支。
4. ssi-integrin Cytoskeleton Signaling Regulates Sensory Neurons Response to Matrix Dimensionality [C] . Andrcia Ribeiro, D. Hughes, S. Vargo, Annual meeting of the Society for Biomaterials . 2011

机译：ssi整合素细胞骨架信号调节感觉神经元对矩阵维数的响应。
5. Biophysics underlying bistable neurons with branching dendrites . [D] . Kim, Hojeong. 2011

机译：具有分支树突的双稳态神经元的生物物理。
6. Sensory Neuron Fates Are Distinguished by a Transcriptional Switch that Regulates Dendrite Branch Stabilization [O] . Cody J. Smith, Timothy O’Brien, Marios Chatzigeorgiou, -1

机译：调节树突分支稳定的转录开关可以区分感觉神经元的命运。
7. Sensory Neuron Fates Are Distinguished by a Transcriptional Switch that Regulates Dendrite Branch Stabilization [O] . Smith Cody J., O’Brien Timothy, Chatzigeorgiou Marios, 2013

机译：调节树突分支稳定的转录开关可区分感觉神经元的命运。

Sensory neuron fates are distinguished by a transcriptional switch that regulates dendrite branch stabilization

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