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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Classic and desmoplastic medulloblastoma: complete case reports and characterizations of two new cell lines.
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Classic and desmoplastic medulloblastoma: complete case reports and characterizations of two new cell lines.

机译：经典和去增生性髓母细胞瘤：完整的病例报告和两种新细胞系的表征。

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Medulloblastoma (MB) is the most common type of brain tumor affecting children. These tumors are a significant cause of childhood mortality and morbidity, and more effective and less invasive treatment options are urgently required. To achieve these aims, it will be critical to develop a more comprehensive understanding of the molecular pathogenesis of MB. At present, there are relatively few well-characterized MB cell lines available to the research community for the study of MB molecular and cellular biology. Here we present the case reports of two children diagnosed with classic and desmoplastic MB, and describe the characteristics of two new MB cell lines derived from these individuals. A number of genes encoding components of the sonic hedgehog (SHH) and WNT pathways were up-regulated in the desmoplastic relative to the classic MB cell line consistent with aberrant activation of these pathways in desmoplastic MB. These cell lines represent an additional resource for the analysis of diverse aspects of MB biology.
机译：髓母细胞瘤（MB）是影响儿童的最常见的脑肿瘤类型。这些肿瘤是儿童期死亡率和发病率的重要原因，因此迫切需要更有效和侵入性更小的治疗选择。为了实现这些目标，至关重要的是要对MB的分子发病机理有更全面的了解。目前，研究界可用于MB分子和细胞生物学研究的特征明确的MB细胞系相对较少。在这里，我们介绍了两个儿童，他们被诊断出患有经典性和去增生性MB，并描述了来自这些个体的两个新MB细胞系的特征。相对于经典MB细胞系，在增塑剂中，许多编码声波刺猬（SHH）和WNT通路成分的基因上调，与这些通路在增塑剂MB中的异常激活相一致。这些细胞系代表了一种额外的资源，可用于分析MB生物学的各个方面。

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