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首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >GFAPdelta immunostaining improves visualization of normal and pathologic astrocytic heterogeneity.
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GFAPdelta immunostaining improves visualization of normal and pathologic astrocytic heterogeneity.

机译：GFAPdelta免疫染色可改善正常和病理性星形细胞异质性的可视化。

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摘要

Neuropathological analysis of cellular mechanisms underlying gliosis and brain tumors is slowed by the lack of markers allowing to distinguish glial subpopulations in normal or pathological human brains. We therefore evaluated GFAPdelta immunostaining in a wide panel of astrogliosis and gliomas, and compared these with GFAP and vimentin. In normal tissue, gliosis and gliomas, GFAPdelta immunostaining was observed in astrocytes with relatively high GFAP levels. GFAPdelta immunostaining was most conspicuous in glia limitans astrocytes. In Chaslin's gliosis accompanying chronic epilepsy, GFAPdelta immunostaining evidenced the glia limitans reactive astrocytes as the source of the dense fibrillary meshwork typical of Chaslin's gliosis. Interestingly GFAPdelta and vimentin immunostainings coincided in normal tissues and gliosis, but not in gliomas. Altogether these results show that combined GFAP, GFAPdelta and vimentin labelling reveals fine gliofilament regulation in normal and pathological brain.
机译：由于缺乏可区分正常或病理性人脑中神经胶质亚群的标志物，对神经胶质细胞增生和脑肿瘤的细胞机制的神经病理学分析变慢了。因此，我们评估了广泛的星形胶质瘤和神经胶质瘤中的GFAPdelta免疫染色，并将其与GFAP和波形蛋白进行了比较。在正常组织，神经胶质瘤和神经胶质瘤中，在具有较高GFAP水平的星形胶质细胞中观察到GFAPdelta免疫染色。 GFAPdelta免疫染色在胶质限脂星形胶质细胞中最明显。在伴随慢性癫痫发作的查斯林神经胶质病中，GFAPdelta免疫染色证明了胶质限脂性反应性星形胶质细胞是查斯林神经胶质病典型的致密纤维网的来源。有趣的是，GFAPdelta和波形蛋白免疫染色在正常组织和神经胶质瘤中重合，但在神经胶质瘤中不重合。总而言之，这些结果表明，GFAP，GFAPdelta和波形蛋白的组合标记可显示正常和病理性大脑中的细丝调节。

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